I may be going out on a limb here, but I’ll take the chance. To the Teeming Female Millions, if you want to post the best looking men in the comics or cartoons, be my guest. 
Betty Cooper’s mother (Archie).
Marvin’s mother (Marvin).
Rose (Rose Is Rose).
Alice Mitchell (Dennis the Menace).
Winnie Winkle.
Lois Flagston (Hi and Lois).
Edda Burber (9 Chickweed Lane).
Blondie. Best chest in the trade.
Sexy attractive:
Black Canary when drawn by Neal Adams.
Miss Lace from Milton Caniff’s Male Call
Attractive by personality:
Rose
Calvin’s mother (I’ll also mention Roselyn, the babysitter. Something about Waterston’s drawing makes them very real and attractive.
Amen. 
I’ve always considered Rose to be one of THE most wonderful women in the comics.
Fritzi Ritz.
I once saw a panel of “Nancy” in which Fritzi’s mascara ran. She looked like Alice Cooper. 
Helen Parr, aka Mrs Incredible/Elastigirl. A dynamite MILF.
Dr Ann Possible, Kim Possible’s mom. Another MILF.
The Baroness–raven-tressed harpy of COBRA, & knows how to work a black leather uniform.
Moonbeam McSwine from “Li’l Abner”. So lazy, but so sexy…
Moonbeam is a honey, but I’ve long since given my heart away to Stupefyin’ Jones.
Jessica Rabbit (Who Framed Roger Rabbit?)
Holli Would (Cool World)
Little Ego (“Little Ego”) (Yes, this is out-and-out porn. But it’s very well-drawn porn.)
Death, of the Endless (Neil Gaiman’s Sandman universe.)
Delirium, of the Endless (Neil Gaiman’s Sandman universe.)
Ever since the election, I’ve dazedly wondered if I’d slipped into a parallel universe.
And now I have proof, since nobody’s yet mentioned Zatanna Zatara.
No mention of Daphne from Scooby Doo? Someone mentioned the Baroness from GI Joe, but Scarlett should be included, too.
Oh, I almost forgot:
Velma (Scooby-Doo)
I don’t read a lot of comics. So I’m slightly surprised no one mentioned Wonder Woman. In high school a friend had a T-shirt of Betty and Veronica making out, which was risqué for the time.
An oldie but a goodie: Betty Boop
Janis, from Arlo and Janis is a hottie. Plus, she’s often getting naked or in her undies.
How about Bugs Bunny in a dress playing a girl bunny?
I was going to mention Daisy Mae Yokum, but I think you trumped my ace.
Dr. Girlfriend.
Being partial, as I am, to redheads:
Jean Grey / Phoenix
Rogue (sometimes a redhead, sometimes more a brunette)
Poison Ivy
Also:
She-Hulk
Arisia Rrab (a Green Lantern)
