What handgun ammunition has the most kinetic energy

If you’re expecting to encounter a bear (coming into your home or you going into their area) you should probably consult the prior thread:

And honestly, any practical handgun is a very poor choice against a bear. A shotgun, or as I opined in that thread, a higher caliber short carbine (45-70) would be the far better choice. Again, a handgun sacrifices most of the advantages of a firearm for a huge advantage in weight/size/concealability.

Of the common calibers that are available, vaguely shootable, and so forth, than yeah, if I had only that choice I’d go with a heavy loaded S&W Revolver in .44 Mag. But it’s still a poor overall choice.