Gödel himself believed that his theorem—more accurately, the impossibility of deciding by a fixed procedure whether a certain diophantine equation has an integer solution—shows that the human mind can’t be computable. The idea of a connection has come up many times in the philosophy of mind, from John Lucas to Roger Penrose.
I think these arguments are, in this form, severely flawed; but in point of fact, I have just received (pretty encouraging) referee reports on a paper in which I argue for a different role of non-computability in the human mind.
And of course, a central point of Douglas Hofstadter’s Gödel, Escher, Bach was how the self-referential constructions enabling the Gödelian phenomena find a role in the human mind.
These articles are serious physics by respected authorities in their fields, having appeared in Nature and Foundations of Physics. This isn’t even a particularly niche topic; books have been written on this sort of thing, including even some popular ones.
Most of these works also contain a great deal of philosophy—which should be expected of such highly intertwined and interfertile research areas, of course. Philosophy has always played a foundational role in the formulation of new scientific theories; it’s really only when considering periods in which the consequences of established science are being worked out that one can get away with disregarding philosophy in physics.
But let’s take a simple example. Consider the humble three-body problem. It’s generally conjectured that no analytic solution—that is, a closed-form equation allowing you to solve the system for every point in time given the initial conditions—exists. It’s also conjectured that the system suffices to embed universal computations—that is, you can encode an arbitrary computational problem into the initial configuration, and the natural evolution of the system will perform the computation.
If that’s the case, then the undecidability of the halting problem immediately implies that there is no closed-form solution to the equations describing the system, and that questions such as whether one of the bodies will eventually be expelled from the system do not have a general answer (although they may be answerable in specific cases).
Consequently, due to the possibility of embedding computations within physical systems, undecidability straightforwardly impacts our ability to predict the behavior even of quite simple systems. (Wolfram calls this ‘computational irreducibility’ and famously argued that it would take ‘A New Kind of Science’ to deal with, although he hasn’t found many takers as of yet.)
Certainly, undecidability and quantum mechanics have often been considered closely akin. I’ve already mentioned the famous episode of John Wheeler being thrown out of Gödel’s (who, perhaps due to his friendship to Einstein, never thought all that much of quantum mechanics) office for suggesting that the ‘point of origin’ of the ‘quantum principle’ is ‘the undecidable propositions of mathematical logic’.
But there are many concrete results apart from the two above I’ve already pointed out. Recently, a highly intriguing and complex result was obtained, relating the halting problem to a problem of deciding how well one can do in a given task using quantum entanglement.
There is much more in this area. To the best of my knowledge, Dalla Chiara was one of the first to argue for the application of Gödelian reasoning to the quantum measurement problem; this thread has been continued in many directions. For simple systems, for instance, one can show that quantum measurement outcomes are random if the measurements encode propositions that are undecidable from the axioms encoded in the system’s state—however, these are not systems subject to Gödelian undecidability—although there’s nothing specifically ‘Gödelian’ about undecidability in systems like Peano Arithmetic, it’s just that Gödel showed that, counterintuitively, there’s always undecidability present in such systems, and that they can never be completed.
Anyway, I could go on and on about this, but I hope the above helps to put the sort of work done in this area into perspective. If this is ‘totally speculative’, then well, pretty much all of theoretical science is.