What songs pick you up when you're feeling down?

Touch of Grey by the Grateful Dead - the song I was thinking of earlier.

Low Self-Opinion by Rollins Band
I Don’t Like Mondays by The Boomtown Rats
The Rainbow Connection, the Me First & The Gimmie Gimmies version
Sloop John B by The Beach Boys
The HIV Song by Ween
Simple Gifts by Tha Friendly Gangstaz Committee. How can you listen to a Quaker rap group and not smile?

Southern Cross - Crosby, Stills, Nash, and Young
Red Rubber Ball - Cyrkle
Pour Some Sugar on Me - Def Leppard
Breakdown - Guns N’ Roses
Cecilia - Simon and Garfunkel

Get Me Away from Here, I’m Dying. — Belle & Sebastian
YATTA! — Happatai (watch the music video, great stuff)
Joining a Fan Club — Jellyfish
King of Spain — Moxy Früvous (or anything by them pretty much.)
Sleeping In — The Postal Service
The Seed 2.0 — The Roots
When I Get You Alone — Thicke
Roundabout — Yes
California — Phantom Planet
Wolly Muffler — Harvey Danger

There’s something in there for everyone, from Rap/R&B, Rock, Acappella, to Soft Glitch Techno.

Hrm, Jason Mraz is kinda doing it for me right now.

I can’t listen to Quiche Lorraine by the B-52’s without laughing. That whole CD makes me happy.

The Allman Brothers don’t really make me happy; they make me homesick. To cure homesickness, however, sometimes I pull out my Conway and listen to Tight-Fittin’ Jeans. Good stuff, that.

Perfect Day by drew, of toothpastefordinner.com. It just makes me laugh and laugh.

Is this by the comedy group from the Japanese show “Silly Go Lucky”; the video has them naked except for fig-leaf underpants?

And for the OP: “Mr. Me” by They Might Be Giants.