Yeah, but the two would be isolated from the rest of the world. Isolated with your wife is still isolated.
It’s not in the USA proper, and certainly not in the lower 48, but San Juan, Puerto Rico has an MSA population of over 2 million. The nearest American MSA over 1 million is Miami, over 1,000 miles away. It’s almost 350 miles to the nearest really big foreign city, Santo Domingo in the Dominican Republic.
Using the 500,000+ mark, I think it’s Boise.