Google.
At work: the company website.
At home: a blank page.
CNN. I like to follow the news.
Mine changes from time to time. Currently, it’s Cat of the Day.
I have three computers (home, work, laptop), and two browsers installed on each (Firefox and IE). Firefox is my default/preferred browser in all cases.
All Firefox browsers: the “home” page is Yahoo Mail, where my primary e-mail account is.
IE at work: the “home” page is my company’s timecard application. It looks all weird in Firefox, so I use IE to log in at the end of every day.
IE at home: the “home” page is…um…wow, I’m not quite sure! I don’t remember the last time I fired up IE at home. I think I keep it around for the occasional e-commerce site that doesn’t like Firefox.
IE on laptop: the “home” page is the web interface to MS Outlook for my company’s Exchange server. It doesn’t play well with Firefox. I don’t really need that interface anymore, though, because I finally got around to asking IT Support to install Outlook on the laptop (I just have to remember to connect to the VPN first if I want to check e-mail from home). I’ll keep IE for the web apps that I have to document, because all of them are only supported on one or two browsers.
Pretty boring, really. 
My “homepage” is an Opera session with all the SDMB forum pages, a few other messageboards I visit, 8-bit theater, and the Astronomy Picture of the Day.