I saw it in an album on The Chive featuring pictures of the olden-days in the U.S. A Google search turns up a bunch of “Orpheum” theatres all over the place so I hoped that a Doper might recognize it.
It is the SF Orpheum. The picture is from its days as a cinema in the sixties and seventies. The marqee has been changed since them, but if the picture showed more of the building you would see the vertical ORPHEUM sign that’s still there to this day.
Here’s another picture of the theatre. One big change since the 1960s is the stairway in front of the theatre leading down to two subways (BART and MUNI).