Another vote for It’s Niles!, assuming Hyde-Pierce, Leeves, and the Frasier writers are on board.
Ducky’s World from NCIS - kind of like a *Murder, She Wrote *series - where Ducky has this private practice on the side with his psychology side - and ends up solving non-naval murders.
That is so amazingly awesome an idea my eyeballs are smoking. I love it!
P.S. It’s “Costanza.”
I’m just a little hesitant in thinking he might be able to carry an entire show, especially into a second season, but I think the Cho character on The Mentalist is helping that show’s popularity at least as much as the star.
The Jack Webb / Joe Friday cloning is being written and performed well and his character is getting progressively more face time. Tim Kang deserves a shot as far as I’m concerned. But an entire show based on Cho, unless it’s modified a lot, might be a niche audience type of thing.
Elmo. I don’t know why they haven’t spun him off from Sesame Street already. As it stands, “Elmo’s World” eats up almost the entire last half hour of each episode; why not just give him his own show already, and let CTW come up with more Sesame goodness to fill that last half hour?
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They did - it’s called the Big Bang theory. 
Thank you. I’d also like to see a show about a young Boston police officer dealing with his two sons while his wife is doing her residency in psychiatry, with his just-past-the-bar womanizing cousin providing comic relie.
I’d call it: Crane Cousins–The Adventures of Martin & Denny.
Cousin Mose from The Office. A Beverly Hillbillies-style show where he leaves the beet farm for the big city, and hijinks ensue.
Titan, with Capt. Riker and Couns. Troi’s continuing adventures as a married couple aboard another starship. It could draw upon the book series, or go in a different direction.
Hank Scorpio, he’s the man, the man who wants to rule the world.