Hagar the Horrible and The Lockhorns. Both feature loveless marriages with domineering bitches as wives. Perhaps the Lockhorns could somehow travel back in time & place to Viking-era Norway.
Or For Better or for Worse and The Far Side, if only because the cast of the former wouldn’t last three weeks. If they were lucky. “…somewhere, off in the distance, a dog barked.”
Peanuts and Zippy the Pinhead. Schulz’s kids could see the world through a veil of acid flashbacks…it would change all of them except Linus, who would be exactly the same.
I thought the obvious one would be Calvin and Hobbs with Frazz
The Op mentioned Cathy and Dilbert. That would be impossible. I’m sure that Dilbert’s Co-Worker Alice would bring the fists of death upon Cathy. At least 'd like to think so.