I was gonna mention Rainn Wilson, who, by the way, I’ve always thought looks like he could be the offspring of Garrison Keillor.
John C. Reilly reminds me of one of the Geico cavemen. Sorry, John; I still love ya.
Sorry, but that is only half a joke. Garrison Keillor and…
Here’s a songabout him by his prettier sister. Whoever made the puppet for the video obviously thinks he’s funny looking too 
Nope, just Keillor.
I have an overwhelming urge to reply to this thread with:
“Your mother.”
But instead, I’ll give you Carel Struycken.
Senator Mitch McConnell.
For the first, look at your own peril.
And even though I think she’s cute, I can’t help but notice Amanda Seyfried’s huge eyes every time I see her.
Portia deRossi.
Lance Reddick.
Paul Giamatti.
Most Politicians the world over.
Me.
Ladies and gentlemen, I present Michael Berryman.
I’ll see your Michael Berryman and raise you Robert Z’Dar.
I just Googled some images to see how she looks now, and either she has had some work done or aged extremely gracefully, but I always thought Molly Ringwald was funny looking.
I actually find Lily kind of funny looking, myself. Here forehead’s way too large, and there’s something about her eyes that’s a bit odd. She’s a pretty kind of funny looking, yes, but it’s a prettiness that comes from being a bit weird looking.
“You broke *that *jaw?”
Hmmmmmm… perhaps the late Elsa Lanchester ?
Seriously?