If you could have any one question answered, what would that question be?
My question would be “Will we eventually migrate off this planet before we die off?”
What don’t I know?
That’s a great question!
Mine would be: what actually happened to Paul on the road to Damascus? Both he and the book of Acts of the Apostles say he had a vision of Jesus. Whatever it was motivated him to spend the next 30 years or so defining and preaching Christianity. If it was a hallucination, it was a doozy.
What important question should I ask?
Once we know the right question, finding the answer is the easy part.
But that calls for a big value judgment on the part of the entity answering the question. And the OP didn’t even guarantee that we’d get a correct answer to a factual question, just an answer. 
Do I look fat in this?
What is 42?
What happens after we die - is there any sort of afterlife that the deceased is aware of?
When will I die?
If I were to ask you if this is the road leading to the village where there is a tavern serving free beer tonight, would you say “Yes”?
Who *did *shoot the deputy?
how can we end violence among humans?
Why do fools fall in love?
Who put the Bomp in the Bomp, Bomp, Bomp?
Before they invented drawing boards, what did they go back to?
Where is the point?
Why?
Why not?
What are the winning Powerball numbers for the next $500M draw?