I generally avoid YouTube, aside from specific links. That is to say, YouTube is not a destination for me like, say, the SDMB is. But recently I’ve spent a bit of time on Funny or Die, and the signal-to-noise is pretty good. I’d check it out.
If you want to find good Youtube videos I would suggest hitting up the Youtube threads on either the Something Awful forums or the Penny Arcade forums. I’m not really a big fan of either website, but I do find that the videos posted in these threads tend to be funny or interesting. Yeah you always get some douche bag posting “hey check out this video my friend made! lol” but they are in the minority.
The Youtube threads posted on the STMB tend to be a bit too tame for my tastes, and usually about 6 to 12 months late to the party. Which is fine, I’m sure, for the more casual internet users. However if you’re looking for more cutting edge, and want to avoid all the crappy lip-syncing videos, then SA or PA are your best bet.
And lastly, if you’re just searching for videos by what’s on the front page or highest view counts then you’ve lost your god damn mind.