“Shit!”
- Most cockpit voice recorders
The security guard in Terminator II:
“This must be my lucky day!”
Such a similar line-reading to “Wait! Where are you going? I was going to make espresso.”
Not his final line, which was “What…are…you…prepared…to do!”
‘Murph’ Murphy, one of the fishermen in The Perfect Storm:
“This is gonna be real hard on my little boy”.
One of the saddest lines ever.
I’ve put your post in a spoiler. If it’s a huge and/or recent thing, you really want to put it in the spoiler.
Yes, because if someone posts a major spoiler that will need to be edited, the best thing to do is quote it so that it appears more than once.
I’ve spoiled yours too.
Darn it terentii! I so wanted to post that one. 
Oh well, here’s another, not quit final words, but he only sings a hymn after that.
Daniel Dravot: Peachy, I’m heartily ashamed for gettin’ you killed instead of going home rich like you deserved to, on account of me bein’ so bleedin’ high and bloody mighty. Can you forgive me?
Peachy Carnehan: That I can and that I do, Danny, free and full and without let or hindrance.
Daniel Dravot: Everything’s all right then.
“Fly, You Fools!”
“Super MAN!”
“For a moment there I thought we were in trouble.” - Butch Cassidy
I’m pretty sure the final line of the monster in Flesh Gordon was “Oh, shit!” but I’m not going to go through the entire movie to find the scene.
“Hold my beer and watch this…” too many times in real life.
Here’s one from The Master:
“The nourishment is palatable.”
Rayburn (Christopher Walken) in Man on Fire.
“Creasy’s art is death. He’s about to paint his masterpiece. And that’s all I say.”
I just had a flashback to a Halloween party I attended when I was working with a bunch of historical reenactors in the '80s: Breaker and Peachy walked through the front door in full uniform just moments apart. (I don’t think they planned it that way, either. It was bizzare!)
Me too. You know there’s now a gene for people who need to travel?
Last line of My Gun Is Quick -
Regards,
Shodan
“Earn this.” --Captain Miller, Saving Private Ryan.
So long, and thanks for all the fish!
If I can post a line from a song:
“Fellas, it’s been good to know ya” - the cook of the Edmund Fitzgerald
Nitpick: Gordon Lightfoot took some liberties in describing the crew’s reaction to the storm. In reality, no distress call was ever sent, and Capt. McSorley’s final transmitted message was: “We are holding our own.”
Michael J. Smith, pilot of the Challenger Space Shuttle: “Uh-oh.”