Inspired from this: Top 10 Melee weapon list.
What is in your opinion the best videogame weapon (melee or not)? My personal favorite is the Scythe of the Celt from Clive Barker’s Undying.
Well, I have a certain fondness for a well-swung crowbar from Halflife, but my all-time favourite is the Lawgiver set to “Incendiary” from Dredd vs Death, mostly because of the results: perps and zombies run {or lumber} around screaming in flames until they finally collapse, leaving neatly burnt skeletons.
There’s quite a few that could make the list, but here’s the ones off the top of my head, in no particular order.
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Shotgun from Doom. Yeah, it’s just a shotgun, but that thing was pretty sweet in the game.
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SmartGun from AVP2. Really useful in those dark rooms swarming with aliens, which was often in the Marine Campaign.
My personal picks?
•The M590 Shotgun from Soldier of Fortune II
VERY nice rate of fire.12-gauge buckshot does wonders in the GHOUL game engine. (sometimes, it just does your heart good to watch a terrorist screaming hysterically as he’s holding up the stump of what had just been his arm 
) Plus, you can club people with it. Possibly my favorite of all time.
•The Chain Gun from Wolfenstein
ANY incarnation of Wolfenstein, really. But I’ll always have a fond place in my heart for the one from Wolfenstein 3D
•'03 Springfield, from Medal of Honor: Allied Assault
A good, solid, weapon. The bolt-action and the relatively small magazine are drawbacks, but hey, nothing’s perfect.
There are probably more, but those are the ones that leapt off the top of my mind.
For sheer coolness, the voodoo doll from Blood has to be up there. And I’ll always have a soft spot in my heart for the powered-up hellstaff from Heretic.
Favorite would have to be the gravity gun from Half-Life 2, I was impreseed with that. It’s more fun for me then it is a weapon.
From that list, for favorite melee weapon, I’d have to go with the crowbar from Half-Life, 1 + 2.
All round favorite weapon for it’s actual use would be the Kar-98 from Medal of Honor. Accurate at a distance, and some serious punch to it. One shot kill for a head shot.
I second the DOOM shotgun. Although I was fond of the railgun in Quake III Arena as well. Beautiful sniping weapon once you got the timing down. Damn. Now I want to play QIII. And I don’t have it anymore. 
The BFG 9000. Hands down.
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- This was an online play/mod weapon, but did any of you guys ever see the Unreal Tournament “fourth of July” redeemer? I can’t remember the name it had on it exactly. It was colored red white and blue, and when you fired it, marching band music started to play and it would explode in fireworks for like 15 seconds, killing anything within normal Redeemer range. So you had to find shelter and stay there until it was done. The first time I fired one I was laughing so hard somebody came up and shot me.
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- This was an online play/mod weapon, but did any of you guys ever see the Unreal Tournament “fourth of July” redeemer? I can’t remember the name it had on it exactly. It was colored red white and blue, and when you fired it, marching band music started to play and it would explode in fireworks for like 15 seconds, killing anything within normal Redeemer range. So you had to find shelter and stay there until it was done. The first time I fired one I was laughing so hard somebody came up and shot me.
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I nominate the Morph Ovum from Heretic.
I like Chaos DM (a Quake 2 mod)'s proximity grenade gun. You shoot out little yellow smiley faces. They lie dormant until somebody gets close enough. Once they detect a victim, they start hopping like mad towards him, going “WHEE!” all the time and chasing him across the map until they get him and explode.
The Gravity Well was also cool. It was basically a portable black hole generator that would suck everything in range into itself and then implode.
The Desert Eagle from Counter-Strike, (old or source, they are both awesome), such a satisfying “BOOM!”. I also share a particular fondness for the shotgun in Doom III, I think I completed 95% of the game using just that weapon, only switching away from it to kill certain end-of-section baddies. If we are allowed multiple selections I will also throw in the stake gun from Painkiller, it requires more skill to use because of the effect of gravity on the stakes which in turn makes it more fun, you gotta love a challenge 
Oh, and the shrinking ray from Duke Nukem: Total Meltdown was cool: shrink 'em, and then step on 'em as they scuttle frantically away. The pipe-bomb was fun, too: “Heh heh. What a mess.”
The nailgun from quake. Hell, its ammo packs had the “NIN” logo on 'em. Neato.
I like the scythe too, but would nominate the “Flaming, Grinning, Laughing, Chattering Skulls of Death” spell from Undying instead.
I’ll second the gravity gun from Half-Life 2. You really get to appreciate it in the Ravenholm level, where ammo is scarce but there are sawblades and other sharp metal objects to hurl into zombies at high speed. And then when it gets supercharged in the final level, letting you hurl opponents around like toys while cackling maniacally.
Automatic pistol with silencer from Medal of Honor.
Quiet, effective and usually could kill easily with a head-shot.
Or the crossbow from Medal of Honor II.
awwwww yeee-eeeaaahhhh…
Definitely the antlion pheremone gland from Half-Life 2 … but then, I’m a delegator.
This needs to go to the arts and entertainment forum.
Moved from IMHO to CS.
My vote goes to the Pistol from Halo, the greatest sidearm a giant green cyborg could ask for. Nothing beats waltzing your way down Blood Gulch, nailing people from halfway across the map with a gun the size of an iPod.