I have a couple I use here and there (well, just there, I suppose, since I don’t actually use one here.) I rotate 'em as I get bored, which happens a lot. My current ones:
“I am in aromatherapy - once a week I tell all my problems to a scented candle”
“Never doubt that a small group of committed individuals can change the world: indeed, it’s the only thing that ever does.” - Margaret Mead
“I’m trying to save my sanity - YOU save the whales.”
I don’t know about best ever, but I’ve gotten some compliments on my sig before.
Well, I got complimented on the first bit about the candy bars. The bit about the nose came later after a lengthy spell of insomnia and was just feeling generally weird and goofy.
Wyrd Sisters. Granny Weatherwax explaining why real crowns don’t look as fancy as theater crowns. 
I used loads of different ones, once upon a time, before i topped bothering.
3 of my favourites were:
“the truth is just an excuse for a lack of imagination”
"Work is the curse of the drinking class " Oscar Wilde
“Religion is for those who are afraid to go to hell. Spirituality is for those who’ve been there and don’t want to go back”
quote 1 and 3, forgot who said them.
sorry folks
I saw someone’s on another board, think it’s also Terry Pratchett:
“Give a man a fire, and he’s warm for an hour. Set fire to a man and he’s warm for the rest of his life.”
Ditto. I almost wet myself laughing when I first read that signature.
That’s a funny post…for me to POOP ON!
Triumph - the insult comedian dog - rules.
You know, I think I have one set up. Hold on.
(previews)
I sure do. Huh. This is probably the only time it has been – or will be – used.
Or not.
I just about fell off my chair laughing at elf6c 's sig line in this thread.
Heh heh. Ralph Wiggum ROCKS!!!