Infinite Crisis and its leadups are going to be big events, of course.
So, what does everyone think is going to happen?
Obvious: Massive bodycount among the second and third tier characters, particularly mystics and villains.
The Spectre WON’T succeed in eliminating all magic in the universe (DC’s not going to eliminate the headliners of 2 ongoing titles - 3 if you’re willing to get into the argument about if the Vertigo DCU is the same as the mainline DCU - and major characters in at least 3 different team books), but he’ll wipe out a lot of the more obscure, silly, or unused magical characters.
Villains United will have a pretty good body count among the more obscure, silly, and unused villains.
Sasha Bordeaux is a goner.
Guesses: Detective Chimp is a dead monkey, too.
Someone in DoV will sacrifice themselves to bond their soul to the Spectre and end his rampage. My money’s on Enchantress. (Alternate possibility, that would be GREAT, IMO, but is unlikely - Jean Loring’s soul and body will be split. Her soul, free of her diseased brain, will be more rational, but still in need of redemption. She will be bonded to Spectre, while Eclipso retains control of her body.)
They’ll at least attempt a new Ragman series after all this, or else an Oblivion book with Ragman, Blue Devil, and anyone else who survives DoV.
Lex Luthor will appear in public again before the VU is done.
A few of the other, more obscure villains, will rise as major threats, like Dr Light has.
The hero community will become more fractured after the revelation about the Identity Crisis mindwiping, and the villain community won’t remain as tight-knit as VU is making them for long.