Here’re a few of the comics I regularly read, and would recommend… for safety’s sake, however, please assume that all of them contain mature content to some degree. VG Cats, Dueling Analogs, and Flipside are the main offenders that come to my mind, but I can’t honestly vouch for the safety of any others. So please be so advised. ^^
The early art is pretty tough to stomach, but Schlock Mercenary usually ranks among my top five; it’s wittty, the author’s science-y footnotes help add atmosphere, and most importantly the writing quality is very, very consistent. There’s a link on the first page recommending that you begin with a later arc, but I’d only advise skipping ahead if you need to assure yourself that the art gets better.
A Miracle of Science was a really, really terrific comic. It was about mad scientists and the special investigators who go after them. The writing, story, and art were all of strictly average to above-average quality, but the creators seemed to enjoy the project, and that really shone through.They also seemed to have had most of the story written before they began, which gave it a very consistent feel. (It has since ended, since the writers basically wanted it to tell one complete story.)
Casey and Andy is, in the words of the author, a comic about mad scientist roommates who periodically die. It’s whole-hearted, nerdy fun, and when it’s good it’s really, really good. There are a few cold spots, and when it ended the author had (at his own admission) lost a lot of enthusiasm… but in general, it’s a great read.
Striptease is about comic artists and romance… it’s fluff, but amusing fluff.
Shortpacked! is a somewhat random satire about a toystore and its eccentric employees. The humor is of variable quality and often leans towards the bizarre, but it’s pretty amusing.
For the first few years of its run Sluggy Freelance was hilarious, engaging, and gripping. It’s since lost a lot of its steam, but I still like it enough to tune in regularly.
I’m not sure exactly what Gunnerkrigg Court is about, but I like it. It’s basically Wednesday Adams’ evil twin, an extremely cheerful (if somewhat sedate) young lady, and her adventures at a Hogwarts-type school which takes Gaimanesque fantasy and infuses it with steampunk trimmings and the occasionally hint of rock & roll.
The creators of the relatively recent Marry Me don’t seem to know where they’re going; they seem to be writing the comic exclusively for the purpose of getting it turned into a romance movie, and some of the obvious plotlines and transparent characters that grow out of that harm the overall product, but in general it’s well-written, well-drawn, and fun to read.
I don’t care for Templar, Arizona at all, but I know a lot of people who enjoy it and I’ll happily admit that the art and writing are both worthy of praise.
Crimson Dark is a rendered comic about pirates in space. Enough said.
Misfile is about a pothead angel, a street racer, and a introverted academic who are stuck with each other after the angel twists reality in a rather unfortunate manner.
VG Cats is a strange, often irreverant, always hilarious comic about video games.
Dueling Analogs is another videogame comic in the style of VG Cats, which is hilarious enough to easily warrant mention.
Speaking of knockoffs, Ctrl+Alt+Del seems a lot like a Penny Arcade clone, but it’s still pretty funny.
Antihero For Hire is about a sulky, working-class hero-for-hire and his antics stopping criminals and exploring his traumatic past. It’s angsty, but in a tongue-in-cheek way that gives the story a keen mix of comedy and (occasional) drama.
Finally comes Flipside. I was split over whether or not to include it, because I just can’t figure it out; in the very beginning it’s quite engrossing, but the bipolar quality of the plot and the occasional typo keep me wondering. It runs the gamute between Amusing Fluff good and Author Desperately Needs A Girlfriend bad, but in general it’s worth reading. Please be warned, however: the content is very decidedly mature, and occasionally disturbing; you can expect nudity, gratuitous violence, sexuality, and a few icky sections that I personally found highly unnecessary. (I would also recommend that you finish Chapter 2, and then go back and reading the prequel, Chapter 0 . It isn’t nearly as polished or well-drawn as what comes after Chapter 1, but it gives a fair amount of backstory.)