There’s another thread talking about titles where you get no real idea what the movie is about. This goes in the opposite direction. I’m mostly thinking of films but will accept books and plays and TV, etc. I have two examples in mind, “Snakes on a plane” and “Hobo with a shotgun”. Not great films, but I think a lot of people, especially when finding out Samuel L. Jackson is starring, could start writing Snakes on a plane themselves. 
So, any other suggestions?
Satch
The Assassination of Jesse James by the Coward Robert Ford
The Englishman Who Went Up a Hill But Came Down a Mountain
The Effect of Gamma Rays on Man-in-the-Moon Marigolds
Well, “The Texas Chainsaw Massacre” pretty much sums up the plot. You certainly know that things aren’t gonna turn out too well for most everyone involved.
Also, slightly off the OP, but anytime you get a “II” slapped onto a summer blockbuster, you pretty much know the plot going in. Specifically, Jurassic Park II, III, and IV. It’s gonna be ringing some changes on “dinosaurs get loose and eat people”.
I disagree with this one. If anything, I think this title is more intriguing than revealing.
WITNESS FOR THE PROSECUTION: there’s going to be a big trial – in criminal court, not in civil court – and the whole thing will surely come down to a key witness for the defense. No, wait; it’ll be a witness that the other side puts on the stand to get sworn in and offer testimony against the accused, right? What the hell was I thinking?
*The Persecution and Assassination of Jean-Paul Marat as Performed by the Inmates of the Asylum of Charenton Under the Direction of the Marquis de Sade *
While the experiment appears in the movie, and is a metaphor for what goes on in the family, the title itself doesn’t really give you any idea of the plot.
Many good ones already, including Assassination above, but I have to agree with the others, Effect of Gamma Rays … doesn’t tell the average Satchmo in the street anything about the plot. I’m inclined to say the same about The Englishman … but I’ve never seen it.
There’s a class of Titles that fit here, only because they are about famous events/disasters. Any film called “Titanic” or “The Hindenberg” lets most people know at least the plot of the last act. 
Of course, it can be subjective. Burke and Wills was completely meaningless to US audiences, but Australian audiences knew what it was about as soon as they saw the name, and would be amused by Americans talking about the shock at the end.
Kill Bill.
Likewise:
The Alamo
Gettysburg
Pearl Harbor
Sink the Bismark!
Snakes on a plane.
It seems you read only the thread title and not the OP.
Abbot and Costello Meet …
The Three Stooges …
Finish out the titles to those movies and you get all the significant information you need.
Mars Attacks!
Attack of the Killer Tomatoes!
Shark Attack!
Attack of the 50-foot Woman
Attack of the Giant Leeches
Attack of the Crab Monsters
Being John Malkovich
Someone Is Killing The Great Chefs Of Europe
This title tells me that it should be a lot like Day of the Triffids meets Spiderman. Am I close?
War and Peace 
Big Booty Cum Sluts, Volume XII.
Apollo 13 fits the criteria pretty well, for Americans of a certain age, while The Right Stuff doesn’t give much information.
All the Godzilla vs. King Kong type movies probably qualify, especially if you’ve seen any of them before.