Oh! Saw one a few weekends ago:
SEME2P
I’m assuming urologist.
Any clues here? Wikipedia link for “PSB”
My old plate was WEBBED1; one day I was on the expressway & was passed by SPIDEY.
It’s amazing how many people thought I was a swimmer, with duck-like appendages.
I thought piano player when I read this. But you never know…
Or am I being whooshed here? 
Like Scarlett O’Hara.
Being a Beethoven fan I once had this as a vanity tag…
DDD-DA
I saw one yesterday that said “STRESSD”. I am a psychologist, so I was tempted to leave my card. 
Two good ones yesterday
JKL&HYD
Dr. Jekyll and Mr. Hyde
And on a purpley-blue car
BLUBRI
Blueberry with a British acccent.
Can’t recall where or when… PAN8
(It’s a vulgar word in spanish.)
HIIQ-CAR
On a Smart car of course.
In my old neighborhood someone had FUN3X on a Thunderbird.
??
Speaker pounds?
Senatus Populusque Romanus = “The Senate and People of Rome”, the initialism that was inscribed on the banners of Roman Legions, along with the number given to the legion.
I saw one a couple of days ago that said HRTOFAU.
[spoiler]Heart of Gold.
The car wasn’t white, though, nor did it bear any resemblance to a sneaker-shaped space ship.[/spoiler]
All right, the notecard I keep in my car has filled up. Here’s what I’ve seen recently:
ES QUE EL - Spanish for…?
DEF STAR
WE MISS U
BLK CHEV - on a black Chevy Malibu
I LUV IT
BLK COP
HZ WLB DN - “His will be done”
CLWN CAR - on a SmartCar
MY 2GRLZ
NARNIA
WTH NOT - “Why the hell not?”
SAVE AIR - but the driver had his window rolled down and was smoking!
TEE HEEE - on another SmartCar
TRVLIN - “Travellin’”
In traffic this morning I was behind a van with a plate reading “ILLIAD”. Alright, so either they can’t spell or are combining a literary reference with being from Illinois.
Then I realized the van was a Honda Odyssey. :dubious:
Sweetie spotted a feminist plate as we were pulling out of a parking space and I had to correct him as to what it said. He read it as IDA WMN “I da woman!” I realized it was 1DA WMN, which is even better.
Block Cop? Maybe the neighborhood watch coordinator?
Or Rev. Will B. Dunn from “Kudzu”
High school Spanish suggests this says “Is that him?”, and the driver is either someone famous or looks like someone famous. Or it could be a homophone for SQL, in which case you’ve maybe got a Spanish-speaking database programmer.
Not so much amusing as puzzling, recently I saw:
1Y 2X
It has to be personalized, but damned if I can figure out what it’s referring to.
A few months ago I was driving right behind a car with a license plate (I kid you not): TITSMCGEE.