In general (always exceptions, blah blah), a four-year difference in age is “greater” for someone in their early 20s than someone in their thirties, greater for someone in their thirties than someone in their 40s, etc.
In particular, there is a hell of a lot of emotional growth and self-discovery / self-defining going on as someone transitions from childhood to adulthood. Four years is HUGE for a 14-year-old and an 18-year-old. In terms of emotional development and maturity, they might as well be on different planets. The difference becomes less huge as both parties make the transition, but that transition is most noticeable and most rapid in the early stages. Most people are in the process of figuring out who they are in their 20s. More of that gets figured out the later in your 20s you get.
There is always self-discovery to be made, of course, but unless you have some screwy denial going on, after a certain point most of it is refining what you already know, not a huge life-altering discovery.
That said, I’m not really in the habit of telling people that they’re too far apart in age to date. If it’s a 20-year-old and a 40-year-old, it’ll give me pause, but I won’t say anything. If it’s 40 and 60, less pause, but still there. There’s no real hard and fast “rule” for me, but over ten years is probably a soft cutoff where I might take notice. For my own personal comfort level, plus-or-minus five years of me, with some flexibility around the 5/6 year mark. Although I’m more likely to go slightly older than slightly younger, I think. If I know someone’s age, even at say three years younger I find myself considering the odds that we’re enough in the same place in life for things to work out well.
Although, oddly, I’m more comfortable considering going younger with women (five years younger than me seems like nothing), than with men. I’m not entirely certain why this is, other than much of my personal experience tends to lend credence to the trope that women mature faster. (Although I have had some – not a lot – of experience contradictory to this, too.)
ETA: Oh – I don’t think it matters which party is older. As far as Daisy and Lance, they’re both a bit neurotic, so I’m not surprised Daisy would freak over something like this. They’re both a little bit emotionally “young” too, despite their big brains and attempts to be older than they are under the guise of being “professionals” or “experts.”