I always find the I-69 signs funny, but my favorite is just north of Pittsburgh in Beaver County.
“This Exit -Penn State Beaver Campus”
I saw a photograph that won a Pulitzer prize back in 1969. Some background: In 1969 Cornell University had a building (the Straight student union) taken over by several armed black radicals who were demanding more African Studies at Cornell. They refused to leave the Straight for a few days but eventually they reached a peaceful agreement with the school. The prize winning photograph depicts the radicals leaving the building carrying shotguns over their shoulders. In the background there was a huge banner that read, “Welcome Parents”. Apparantly the radicals had chosen parent’s weekend to carry out the infamous Straight takeover and no one had taken down the sign.
After I saw that my favorite phrase to complaining freshman became, “Welcome to Cornell”, for example:
“I went to my exam expecting to get the full twelve inches only to find out that there was actually fourteen.”
Welcome to Cornell.
“A drunken co-ed just came into my room and took her clothes off, she then pissed on my basketball and proceded to pass out.”
Welcome to Cornell.
Why is it snowing in October?
Welcome to Cornell.
The “Strange Pharmacy” reminded me of this one.
I grew up in Chattanooga, TN, and for many years the “Hemlock Pharmacy” existed on a main thoroughfare. Unfortunately, they’ve gone out of business. Hmmmm. Wonder why??
Then, when I went to college in Maine, on my way to school, I saw “Yankee Shooting Supplies”. Thought about stopping by since I figured it was open season on Yankees. 
-Lsura
The little mom & pop sore had a big sign out front
‘Bunnies and Levis’
just shake my head because I still don’t get the connection…
BTW, The warning sign for swans you should heed, they are quite nasty and capable of breaking bones! Damn near killed my father-in-laws big male swan with a 5 gallon bucket, protecting my then 3 year old son.
later, Tom
guess that blows my sig…
later, Tom