No, it takes liberties for maximum New Jerseyness. When I first saw the credits I was struck by the appearance of the “tanks” on the Turnpike – if he left the Lincoln Tunnel, he wouldn’t drive that far south to get to the Newark/Elizabeth area, where the rest of the landmarks are. But everybody who drives through NJ that way rememkbers the tanks.
The cathedral is probably in Newark, although it could be Elizabeth – you can see a similar one from the Turnpike. What Exit? will be along soon to pin this down, I hope.
Despite the creative interpretation used to arrange the locations, I think it does a great job of capturing the concept of “driving in New Jersey” in general, at least from my point of view as a person who occasionally drives through New Jersey from New York. You definitely hit those sequences of industrial landscape/old town/new suburb within relatively short distances.