Who’d win? How would this battle ensue?
How many snakes? What kind?
If the combined snakes outweigh Jack, and if they are poisonous, and they have the jacked up intelligence almost all movie critters do – say they’re genetically engineered and then fell in some nuclear waste – and if he can’t just jump off the plane and blow it up behind him, the snakes would win.
How can a guy torture a snake? You know in the middle of his battle with the snakes, Kim would call with a crisis.
Actually, wouldn’t Kim get bit by one of the snakes?? 
No one. The snakes would bit Jack and he’d die. But few snakes have pilot’s licenses, so the plane would crash.
How are they going to keep the plane flying for 24 hours?
A Boeing 747-400 can fly for at least 20 hours. cite
Maybe it would take 4 hours for the snakes to go through the TSA screening?
It’s possible for a snake to get rattled.
That’s never stopped Jack in the past.
The biggest flaw I see in Jack’s plan is the difficulty of disarming a snake right before it goes off.
Mid-air refueling, my good sir.
“I need a refueling now, or MILLIONS WILL DIE!”