Buck Dharma, solo in question kicks in at 15:55 on this YT vid.
Blue Oyster Cult, Astronomy, from Some Enchanted Evening.
At 15:55 Give it a little time, it takes a minute to get going.
What’s your favorite?
Probably a sentimental favorite more than anything at this late date, but I’ve always loved the one in the middle of “Like a Hurricane” (Neil Young, of course).
Yes! Love NY, love that song. Good choice.
Have you heard Year Of The Horse? That’s my favorite NY/Crazy Horse.
Oh my god, I LOVE this solo. Maybe not my all-time favorite, but I can’t think of anything better right now. I listen to it so often I cringe at what I think is a screw-up at 17:30. I basically know every note. Great choice.
First the drum solos, then vocals, the lead guitar has some great solos throughout. at 3:30 the vocals and guitar go back and forth answering each other.
Do I have to pick just one? I love the short-8 bar solo by Andy Summers on the Police’s “Driven to Tears.” For a longer one, I’d go with Verlaine’s extended solo on “Marquee Moon” (Lloyd also has a solo earlier in the song.) Yeah, it’s a bit of a hipster-ish choice for a favorite guitar solo, I suppose, but it completely blisses me out every time I hear it. James Honeyman-Scott’s solo from “Kid” (the more conventional choice) or “Tattooed Love Boys” would also be up there in my all-time favorites list.
Layla, just before the bridge to the piano portion. It’s not really a solo, but the lead guitar (I think it is Duane Allman, not Eric Clapton) makes the guitar wail the main melody a few octaves above the rest of the band like Yitzak Perlman with a violin. This is the closest rock and roll music comes (heh heh) to inducing an orgasm. It’s in such a high range I’m not sure if I can hear it anymore, but it sounds like the solo of an angel.
My favorite is a tie for first. Both Randy Rhoads, both at the end of songs:
Revelation/Mother Earth
Mr. Crowley
Peter Frampton’s Something’s Happening. The solo reminds me of a sunny day.
I’ll have to listen to that RH - looking forward to checking it out.
Me? All time has to be Jeff Beck - album Truth, song Let me Love You. Opened my eyes to what simple, brilliant guitar work could sound like - transformed me as a listener and aspiring player. I tried to articulate why here: Helping out with some blues guitar recommendations - Cafe Society - Straight Dope Message Board
There are many others, but another song that, to me, represents the best rhythm+lead guitar work I look to as a guide is the live version of Tumblin’ Dice off the long-bootlegged, now-available Belgian Affair CD by the Stones. Mick Taylor could not be more lyrically fluid - simple yet melodic with the best tone around - and Keith demonstrates his ability to play haiku-perfect simple rhythm work. Pretty much the bar to hit as far as I am concerned: Rolling Stones Brussels Affair Tumbling Dice 1973 - YouTube
There are way too many. Three that popped into my head immediately:
Steely Dan - My Old School, solo by Skunk Baxter.
Steely Dan - Kid Charlemagne, solo by Larry Carlton.
Rush- Villa Strangiato, solo by Alex Lifeson
Oh thought of another
Triumph - Headed to Nowhere, dueling solo Rik Emmett and Steve Morse
Frank Zappa - “Transylvania Boogie”
Frank Zappa, Inca Roads. The song was recorded in a studio, except for the solo, which was recorded in a concert in Finland and dubbed into the song. Or so I’m told.
James Honeyman-Scott… I just re-listened to their first LP the other day, how freaking wonderful and distinct was this guy in his early-20s? Yeah the word unique gets thrown around too much, but he really had it going on.
I’m generally pretty easy-going on the topic of drugs, but god I hate them sometimes.
Yeah, it’s a shame. I only really “discovered” that first Pretenders LP about 7 years ago, but it’s become probably my most-listened to album of all time. (“Discovered” because I had heard it a few times before, but it hadn’t clicked with me yet. Believe it or not, it was Guitar Hero 2 with “Tattoed Love Boys” that got me to go back and explore them a little more closely.) The drums, the guitars, Chrissie–everything on that album is awesome.
Totally agree. It is a truly perfect album. By the way, puly, I like your choices. Angular and smart.
Eric Clapton with Delaney and Bonnie, “I Don’t Want to Discuss It”: I Don't Want To Discuss It Eric Clapton with Bonnie and Delaney - YouTube
or
Frank Zappa, “Yo Mama”: Yo Mama -Frank Zappa - YouTube
Thanks. Yours, too. Post-punk is right in my wheelhouse, for some reason, so my tastes tend not to be the usual fluid, blues-based guitar solo. (It’s somewhat odd, as that’s what I grew up with–lots of Zeppelin in my teenaged years. 
Plus Chicago blues were always a favorite of mine.) If I went more with blues-based rock, it’d probably have to be some Hendrix tune. Maybe “Voodoo Chile.”
Comfortably Numb
It’s short…it’s not particularly technical…but it’s indeed a favorite: Robert Quine’s skronky goodness in Richard Hell and the Voidoids’ “Love Comes in Spurts”.