If they made a live action movie of the Simpsons, would could you see playing a family member or one of the townspeople?
There are few people you can find out there that LOOK like Homer Simpson. It doesn't have to be base JUST on looks. It could be VOICE, DEMEANOR, STATE OF MIND, INTELLIGENCE, ATTITUDE, DIET (i.e., beer), SHARED CHARACTERISTICS, LOOKS, even ODOR! Just the person who has the most likeness to the character.
Don't limit yourself to JUST Actors, It can be CELEBRITIES, POLITICIANS, even a PERSON YOU KNOW... but you must explain the person you know.