The crew of the USS Sweathog
Captain Gabe T Kottair
First Officer A’nld H’ro Chak, a Klingon
Fred “Boom-Boom” Washington, tactical officer
Julie Kotter, civilian manager of 10-Forward, and the Captain’s ex-wife (she chained her name, a little, after the divorce)
One E’p Stine, half-android, half Puerto Rican, half Jewish; Helm
Lt Cmdr. Bar Breeno, the Psychlo Chief Engineer
Lt. Hotsi Totsi, ship’s counselor
Dr. Woodman, the exasperated CMO
J.A.Q.-brilliant!
Captain Perry Mason (Raymond Burr)
First Officer Drake (William Hopper)
Engineer Hamilton Burger (William Tallman):
Dr. Tragg (Ray Collins)
Communications officer Della Street (Barbara Hale)
Thanks!
Crew of the WNYX Enterprise (Newsradio)
Captain: Jimmy James
First Officer: Dave Nelson
Android: Bill McNeal
Chief of Security: Catherine Duke
Ship’s Counselor: Lisa Miller
Chief Engineer: Joe Garrelli
Doctor: Beth
Ensign: Matthew Brock
These are the adventures of the USS Seinfeld…
Captan: Jerry Seinfeld.
First Officer: Cosmo Kramer
Communications officer: Elaine Benis
Navigator: George Costanza
Chief Engineer: David Puddy
Redshirt: Newman
Can Newman be ALL the red shirts? He could die every week. Maybe several times in each episode.
I think the Liz-ard should be Captain but what’s really odd is no Dr. Spaceman?!? This is the role he was born for!
The Muppet Show
Kermit the Captain
First Officer-Scooter
Ship’s Counselor-Miss Piggy “HI-YAAH!!! You’ve been counseled.”
Tactical Officer-Gonzo The Great
Redshirts-the chickens
Weapons Officer-Lew Zealand and his Boomerang Fish
Chief Engineer-Beaker
Ship’s Doctor-Bunsen Honeydew
Ship’s Entertainment-Dr Teeth and The Electric Mayhem
Secret weapon-Animal
10-Forward- Fozzie the Bear
Food replicators-Maintence and Programming Technician-The Swedish Chef
Admiral at Starfleet HQ-Sam The Eagle
The Borg-Staler and Waldorf “Resitance is futile. You will be heckled.”
Underfoot Ensign-Robin The Frog
Transporter Chief-Rowlf The Dog
Good one.
That’s Kermit T. Frog.
But I’m seeing Miss Piggy as Lwaxana. Now I don’t think I’ll be able to watch the real Lwaxana without seeing Miss Piggy.
Miss Piggy has always displayed the tact and sensitivity to properly deal with any problem a crewmember brings to her. 
Lwaxana was just annoying. I’m surprised Wesley isn’t her kid.
These are the voyages of the USS Minnow
Capt. Jonas “Jean-Luc” Grumby
1st Officer Willie “Ryker” Gilligan
Chief Engineer Roy “Professor” Hinkley
Chief Financial Officer of Starfleet Commodore Thurston Howell XXIX
Counselor “Lovey” Howell
Operator of 10-forward Ginger “Grant” Guinan
Ensign Mary Ann “Wesley” Summers
The ship seems woefully understaffed, but it won’t matter as it’s only a three hour mission–A THREE HOUR MISSION.
I totally forgot Nazi Doctor Spaceman. And just threw it to Jenna for the medicinal brandy and exotic STDs.
Dude, Doctor SPACEMAN! It fits so much better!
Star Parks and Trekreation
Captain: Leslie Knope, who micromanages every little thing on the Enterprise
First Officer: Ben Wyatt, with Spock ears, bc he’s a trekkie
Dr: Ann Perkins, the captain’s longtime friend and crying towel
Chief Engineer: Ron Swanson “I cannot increase warp because of the laws of physics, which are irrevocable and inviolate. We’re done here.”
Communications Officer: April Ludgate, who hangs up on all incoming transmissions
Security Officer: Andy Dwyer, actually FBI agent Burt Macklin
Navigator: Tom Haverford “But Lesleeeeeeee, I look dope in gold!”
Counselor: Chris Traegor “This is literally the weirdest emotion I have ever experienced.”
Ten Forward Hostess: Donna Meagle “Uh uh, you had enough synthehol, bitch.”
Redshirt: fall guy Larry/Gary/Harry Gergich
Isn’t he still missing a half? 
With Donna as Transporter officer and C.J. Craig as Security chief.
The crew of the USS Milwaukee
Captain: Howard Cunningham
First Officer: Richie Cunningham
Dr: Marion Cunningham
Chief Engineer: Ralph Malph
Communications Officer: Mitsumo “Arnold” Takahashi
Security Officer: Arthur “Fonzie” Fonzarelli
Navigator: Potsie Weber
Ten Forward: Al Delvecchio
Wesley Crusher proxy: Joanie Cunningham
Redshirt: Chuck Cunningham clones
When Patrick Stewart hosted SNL in the early 90s, they did this very skit. I remember that Charo fell in love with a Ferengi.
Simpsons Trek
Captain Picard - Grampa
Commander Riker - Homer
Counselor Troi - Marge
Data - Ned Flanders
Worf - Barney
Dr. Crusher - Lisa
Geordi - Carl Carlson
Wesley - Bart
Tasha Yar - Maude Flanders
Chief O’Brien - Grounskeeper Willie
Ill-fated redshirt - Hans Moleman
Lwaxana Troi - Edna Krabappel
Romulan Commander - Mr. Burns
Romulan Sub-commander - Smithers
Borg unit (all of them) - Principal Skinner
Borg Queen - Agnes Skinner
Ferengi (all of them) - Moe
Loony Tunes
Captain Yosemite Sam
Science Officer Bugs Bunny
Communications Daffy Duck
Engineer: Wile E. Coyote
Navigation: Road Runner
Medical: Sylvester
Red Shirt Wile E. Coyote (dual role