Zoe to Mal in Firefly - “Sir, I think you have a problem with your brain being missing”
Agent K in Men in Black - “Ma’am, the FBI does not have a sense of humor that we’re aware of”
House (in response to “couldn’t I get pregnant some other way - like from a toilet seat or something?”). “Sure. Of course, there would have to be a guy between you and the toilet seat, but yeah.”
Roseanne (in the episode where Dan’s insane mom - hilariously played by Debbie Reynolds - shows up and is trying to kill him) - “Don’t call the hospital, Dan! They could take any one of us away!”
The whole last season of that series was horrifically bad, but Debbie Reynolds single-handedly redeemed that one episode. “I’ve fallen in love with the (giggle) burying him alive idea!”
The only funny line in the entire series, and it was the first joke in the first episode. Oh, the time I could have saved by changing the channel after that…
I’ve always found the whole thing about popular culture where people can without a hint of irony wear a mass produced and very popular t-shirt that proclaims their individuality amusing.
So the line where Brian says to the crowd that they are “all individuals” only to have them parrot back the line in unison, followed by the lone voice saying “I’m not” has always cracked me up, and I find myself hearing the lines in appropriately ironic circumstances every frickin’ day.
Chandler: And there’s Daddy!
Monica: That can’t be your father
Chandler: Believe me, I’ve been saying that for years!
ETA: Chicken pot, Chicken pot, Chicken pot piiiiiieeee is a great call. I agree with everything Ol’ Gaffer said. In a medicre show, that one episode is a masterpiece.
“Everybody freeze … everybody down on the ground.”
“Well, which is it, sonny? If’n I freeze, I can’t rightly drop. And if I drop, then I’m gonna be in motion.”
There are also too many from the Simpsons to list here.
Lord John Whorfin: Where are we going?
The Red Lectroids: Planet Ten!
Lord John Whorfin: When?
The Red Lectroids: Real soon!
I die laughing every time I hear these lines.
Also:
John Bigboote: John O’Connor, break the window!
John O’Connor: Why me, John Bigboote?
John Bigboote: It might be booby-trapped!
John O’Connor: Oh.
Thanks IMDB!