You’ll be in the heart of downtown.
That means you’ll be a stone’s throw from our new ballpark. Not that it does you much good, because I checked the Padres site, and they’re going to be up in LA and won’t have a home game until 7/26.
You’ll also be close to Seaport Village. That’s a nice place to walk around and people watch, and enjoy the view of the harbor and the nice weather. There are some places to eat there, and it’s nice to hang out.
For nightlife, you can walk east to the Gaslamp Quarter. There you’ll find some restaurants (many of which have good reputations, but I’m not personally familiar with). Check out the Gaslamp’s website here for a map and some details.
We also just received the USS Midway, which is moored down in the neck of the woods you’ll be hanging in. They just opened a museum on board (which I haven’t been to) but you can check it out here .
A little bit farther away (probably less than 5 miles or so) is Balboa Park. In there you’ll find tons of museums (Reuben H. Fleet science musem - with IMAX theater, Museum of Man, Museum of Art (which has an exhibit called St. Peter & the Vatican that I’ve been meaning to check out), and some other stuff. It’s also home to the San Diego Zoo. The zoo now has nighttime hours for the summer, so after a day of conning you might still be able to fit it in.
As for the weather, you’ll most likely be comfortable in shorts most of the time, but bring a sweatshirt at night. You’ll be coastal, so it can get a bit nippy. (well, at least according to my SoCal sensibilities.)
Let us know what time you have free. I’m always up for meeting other Dopers. My email is in my profile if you have any other questions or want more information on San Diego.