Basically a motivational session interspersed with his song “Whispering A Prayer” about how he achieved success and his advice to other aspiring musicians. Pretty cool. Link to other Vai “speaking session” videos too, one of which I am watching now. Say what you will, dude is a practiced technician and has absolute mastery over the electric guitar.
Anyway, check it out: http://www.youtube.com/watch?v=atGBKuCJ-Jc&playnext=1&list=PL8E7E210E62052257