I’ve said it before (in another thread about attractive cartoon ladies), but George Shrinks had a pretty appealing mum…
Didn’t read whole thread - was Horatio Altuna mentioned? He not only drew sexy women, but the situations that he had them lord over - quite entertaining.
One of my favourite characters…“Cat”. (thought I’d never locate this comic again, but after years and years - struck gold)
NSFW:
How about Lois Lane, Lana Lang, Wonder Woman, and Supergirl from the Silver Age of DC comics (the ones I grew up with)? They were all pretty hot!
The one who really turned me on as a twelve-year-old was Leeja Clane in the Magnus, Robot Fighter comics. What a luscious babe! :o
Wilma.
Is Vampirella too obvious? Nice to see a Druuna mention already.
I like Lana for being a redhead…featuring in 50’s sweaters and her awesome Insect Girl costume.
Wasn’t there sort of an American version of Modesty Blaise? Not quite the same thing but a buxom businesswoman. Written as a serious strip. Her husband disappeared and was presumed dead at some point, and IIRC when the strip ended, it turned out he’d been captured by her arch enemy and brainwashed to hate her. I think at the end, the strip had him falling to his death from a skyscraper after he missed her when rushing forward to push her off. Does that ring a bell for anyone?
Elvira, Mistress of the Dark! 
:o
Quite frankly, I always preferred Lana to Lois myself. :o
Lana always seemed to be drawn with broader shoulders than Lois was.
Strictly, not a comic or cartoon, but still hot. 
Yeah. You just hope for her sake she doesn’t sneeze in that outfit! :eek:
She had a comic book.
Ran for years.
Well, if we’re going there, my vote goes to Omaha the Cat Dancer.
As a more serious answer to the OP: Lola Granola, from Bloom County. How Opus wound up with such a babe is beyond me.
Omaha is cute, but I think Joanne is prettier.
How about Bonnie Bunny?
(Red Sonja also comes to mind.)
… Or not! :o
NSFW!!!
I guess you could look at it that way, but then again so did The Brady Bunch, and I wouldn’t consider them comic characters.
[Moderating]
Eddie the Horrible, while the images of Cat at your link were all tiny thumbnails, some of them were definitely NSFW. I’ve put the link in a spoiler box to comply with our two-click rule.
So you really like the mean-girls type? Because I can’t remember her ever not looking like “queen bitch cheerleader” stereotype that she was designed to be.
Of course, I always thought Shego was cute, and she’s a flat out villain. Though, I admit, her voice has a lot to do with it.