Third world labor issues.
Kids.
People’s health & surgery.
Band or movie ranking.
Religion
Sports
Computers
Cell phones
Musicals on or off Broadway
SUVs
The 2000 Election. Mention it and I walk away (The same holds true for Iran-Contra or anything to do with Reagan, really. I don’t care.)
Pop culture
The West Wing
Anti-Globalization
Ninety-eight percent of television
The new Star Wars films (I saw Ep.2 because I got to the theater early and decided to avoid waiting in line later on)
The terrible peril posed by ‘Frankenfood’.
Sports
I know a lot of people have said it, but really. Sports.
I don’t watch sports. Not even the World Series. Nlot even the Super Bowl (not even the halftime show). Not even the Olympics (although I broke down this year and watched the opening ceremonies, 'cause they were from SLC).
I don’t read the Sports pages. I didn’t even know the Boston Globe ran a comic there (Tank McNamara) until my wife pointed it out to me.
I bicycle. I ski. I swim. I play racquetball. But I don’t follow any professional or amateur players in any of these. If I’m not doing it, I’m not interested.
Sports (except boxing)
Local politics – christ, what a snore-fest!
(Mushono, I don’t know how a human being could not like music. I’m thinking about starting a thread on that.)
Vitamins
New car models
the arab-israeli conflict. i love politics, but the bulk of my school year has consisted of gusest speakers telling us about bias and misrepresentation in the media. oh ok something new, how very modern of you.
hearing about other peoples dreams.
The West Wing
Survivor
organic gardening
egg substitutes, whether a chicken is free range or not, soy anything.
Your “I loved and lost how could he do this to me” tortorously self-involved 3 hour sobfest.
There is a 30 minute time limit on self-pity.
Anal neatness. Been there, had that phase, adds nothing to my life.
Designer just about anything.
Those state quarters.
Hemp, patchouli, dreads, Earth Festivals, etc. (although I remember having no aversion to pot in college! 
)
video games and comic books.
name brand/expensive makeup, shampoo, etc.
Cheesy modern dance/dance with the chi/spiritual NIA hooey.
Couldn’t care less about;
Hunting/Fishing
The environment
Survivor
Stocks/Stock market
hearing about your day at work/school
sports
weddings
halloween
Video Games
How well your dog did in the dog show
watches
yoga
Star Trek
Whiney liberals
Traveling-especially to a foreign country
fingernail polish
"The Classics-books or movies
Art
your car
the movie you watched last night
the ozone layer
gardening or tomato plants
what aches, pains or diseases you have today
Science Fiction anything (Star Wars, Star Trek, Star Who Gives A Fuck)
Role Playing Games (Cecil’s column on D&D was priceless - “…mathematical computations that would constipate Einstein…”)
Ren Faire stuff
Monty Python (Sure, it was funny. When I was 14.)
Anime (it must be the eyes)
Comic books
Ok, why not:
Survivor
Basketball
Hockey
Soccer
Nascar
Golf (which elsewhere wouldn’t seem like much, but in Phoenix, that’s saying a lot)
Religion
Children
Father’s Day
how cute your kid was when he threw up the other day
how fat you think you are…or…
how much weight you lost
getting an SUV
vegetarians
working out
putting the seat down/ which way you hang the t.p.
Harry Potter
celebrity murder of the week
The Lakers
the flag
clothing
piercings
tattoos
Jesus
I’m going to second, third, whatever: working out. I’m sick to death of people talking about their classes, how many situps they did, how skinny they’re getting. Enough already. You work out. You joined a gym (I can’t afford to, but I try to do my yoga at home, and you don’t hear me blabbing on about it every day). You’ve got a regular gym schedule. Fantastic! Great! Good on you! Why is it necessary to share this information with me? If I sound bored when you tell me, it’s because I am.
Actually, I kind of like hearing about someone accidentally farting when they tried to do a certain yoga pose, but that’s such an isolated anecdote it’s not even worth tossing around as something redemptive.
Religion
Politics
Most non-motorized sports + Nascar
Most music past 1980
Current events in other countries
Current events here for that matter. i.e. Enron, put them in jail already, I don’t care.
Vegaterian food
Primetime TV
Cooking, home improvement, and shopping channels
Basically, just a self-centered guy with much more me time since I don’t care much about anything else.
Oh boy, sign me up for the “couldn’t give a flying f*ck at a rolling donut about the World Cup” list.
Hubby is all about the World Cup, even getting up at 5 a.m. to watch games and stuff. Then he wants me to get excited when he says, “Can you believe it? Elbonia beat Transylvania one-nil!”
I do the wifely duty and smile and nod and make exited “Oooh” noises, but really…Do. Not. Give. One. Molecule. Of. Crap.
When’s that thing over, anyway?
Sports! I could really care less. Truly.
Cars. Listening to people talk about their cars is not something I enjoy in any sense of the word.
Personal Hygine. I tend to want to know everything. This isn’t something I want to know.
Bodily Functions of any kind/sex lives: See above.
The decreased morality of today’s society.
Celebrities. WHY SHOULD THEY BE ANY OF MY BUISNESS? WHY SHOULD I CARE?
Video games: If I do not own and play the game, it is unlikely that I care what exactly you are doing in it. This goes double for anything resembling Everquest.
Mainstream Entertaiment: I could probably survive with no TV whatsoever. Same goes to more or less most musical groups.
What you think of my personal choices: I could care less if you think I spend too much time doing X. Really.
Great thread!
Oh, add how much you want your significant other to be here now. That’s certainly not something I want to hear about.
Given that it has taken over my office lately, I would have to say:
Baseball.
Talking about baseball.
Speculating about baseball players.
Baseball games.
Bat and ball construction and composition.
Obscure rules of baseball.
Favorite foods eaten while watching baseball at home/at the stadium.
Best baseball players of all time.
Worst baseball players of all time.
Mediocre baseball players of all time.
Thank you, everyone who said television. I hate tv. I find it boring and insulting.
Celebrities
Sports
Role playing games
Computers
How drunk you got last weekend (I really don’t care)
Why everyone should take up bodybuilding
Food paranoia
Hollywood and celebrities in general