Things that come to mind for me are Facebook and Myspace. I will never be interested. They seem less interesting than blogs which I am only slightly interested in.
And would anyone like to comment on ending a sentence with a preposition?
Team sports. I just don’t get the appeal. Televised, fantasy leagues, commentators, and analysts…ugh.
I too, have no use for Facebook or Myspace. I too, have troubles with terminal prepositions. 
I no longer have any use for Hockey, I use to enjoy it. I have no use for Nascar, I never have.
The large variety of reality TV shows, from Idol to any of the others leave me cold. I just don’t have an interest.
Jim
Sports of any kind.
Parties.
Children.
Running.
I’ll get there eventually.
What Der Trihs said. Also, non-furry pets. I’m strictly mammalian with my companions.
TV sitcoms. The last time I enjoyed them was in the third grade watching Happy Days reruns.
Team sports. My city’s team might win the World Series for the second time tonight, and I Just. Don’t. Care.
Political commentaries from anyone other than George Will or Michael Kinsley. Those two are the only ones I’ve heard who don’t sound like whiny self-righteous high school nerds or total nutjobs.
I like children in general, but I have no interest in having my own.
Sports, pets, children, reality shows, cars, sex, fashion, Harry Potter, porn, parties, drinking, etc.
Sounds like you should live to a ripe old age.
Personally, I’ve no interest in TV, Sports or horror films / books.
A person cannot be interested in everything. Sometimes it just seems sensible to recognise that self-evidently fun and interesting stuff has to be given a body-swerve. You need boundaries to what you do and do not do.
A good example for me would be skiing, or any winter sports. A man like me really should know how to ski - I love sports, the more adrenaline the better. I also love the outdoors, do a lot of hill walking and some simple winter mountaineering routes when it gets cold - I’m used to doing stuff in the snow. You just have to acknowledge that you can’t be interested in everything, particularly when you’re busy enough with all the stuff you are into - I am certain that skiing is a fantastically rewarding pastime, it’s just that I’ve never done it and feel happy to leave it at that.
MySpace and Facebook, though I fear I’m going to have to get a MySpace sooner or later.
Harry Potter. I’m so happy the damned series is over, though I know I got to live through the last of the movies. Most people leave me alone about it, but there will always be some die-hard fans of the books that will not understand that I don’t read Young Adult books about Wizards because I don’t like YA books about wizards. Yeah, yeah, it’s about more than that—whatever. I didn’t like YA books when I was a young adult.
-Watching sports on TV. I like to play sports, but watching them is really boring.
-Baby Einstein, which some acquaintances insist is a must-have for my almost 18-month old (I’d rather he explore in person instead of watching TV)
-Candle parties and anything made by Pampered Chef (STOP inviting me, dammit!)
-Britney Spears’ custody situation
-Extremely graphic horror films like Saw, Hostel, the Trippers or whatever - I think scary movies without any gore are far more compelling, scary and interesting than movies that just try to freak me out on the ick factor. Other than recalling how we used to watch them in high school to prove we weren’t grossed out, I don’t get at all why they’re popular.
Baseball.
Politics.
Religion.
Fashion.
Horror Flicks.
Drugs.
Video Games.
Children.
Celebrity Gossip.
Indian Cuisine.
People that try to cram their religion down my throat.
BMW Cars (sorry but they are driven by wankers).
Those sites (Livejournal is another one) bug me because you have all these vague acquaintances, almost none of which you’ve met face-to-face, who are designated as your “friends”. Yeah I’m sure if something like a hurricane or fire comes along and trashes your house they will all be there the next morning, perky and smiling and all too ready to lend you moral and monetary support.
Casual sex. I know we’ve had tons of threads (and more than a few arguments) on this issue, but sharing myself, my body, and the latter’s fluids with an almost complete stranger wigs me out, and I can’t for the life of me grasp the appeal.
Does what people normally call ‘having a life’ count?
Chores, work, bars, sports, outdoor activities, TV, news, people, movies, music, art, books, volunteering. There are, of course, a few exceptions to some of those. There are certain TV shows, movies, and music I don’t mind watching/listening to. I’ve also read quite a few books, more to kill time than anything else.
Sports, MySpace, Facebook, clubbing, recreational drugs, casual sex, crafting.
Scrapbooking. I just don’t see the appeal in spending your life gluing frilly crap, antiqued cardboard letters, fake flowers, and sequins around pictures of other people’s lives.
Keeping a photo album and tickets, and writing in dates and little notes I get. This, I don’t get.
babies or children
Harry Potter
sports
christmas
marriage