Medium Large
Irritability
All the stuff over at Sun Comics
and Buffman, when it’s updated.
As well as Sinfest, SoreThumbs and Wapsi Square.
I don’t know how many actual comics I read, but there’s about 24-30 I look at MWF, 12-18 Tuesday and Thursday, and a few miscellaneous ones over the weekend. If I get pointed to a new comic and wind up devouring the archive within a day so fast I forget which reality is real, it gets added to my list.
Currently, the top comics I make sure I read that haven’t already been listed are:
Questionable Content - It’s a comic for indie music lovers, but I’m not and I find it entertaining as hell.
Order of the Stick - For D&D players. The art’s intentionally spare, but the writing is brilliant.
Two Lumps - A short, greyscale comic about a couple of cats.
NPC - A fantasy novel in book form. Reasonably well done and quite gripping at times.
The rest have either been mentioned or aren’t great, but I read them out of habit.
Something I found out works well with Firefox: Since I have so many comics, I sorted them into directories according to which days they update. Firefox has an option in the bookmark folder to “Open All Tabs.” Go to the current day’s folder, click that, and the funnies are loaded right up to read. 
Probably not too useful on a non-broadband connection, though.
Miracle of Science
VG Cats
8-bit Theatre
Sluggy Freelance
Ghastly’s Ghastly
All previously mentioned.
Schlock Mercenary ( points at username ) Here it begins !
It’s a scifi comic about a bunch of space mercenaries. Funny, with lots of explosions. "There is no overkill, only ‘open fire’ and ‘time to reload !’ " 
Sluggy Freelance
Bob and George
Adventurers! (my first webcomic. A fun look a RPGs and video games in general. Too bad it’ll all be over soon. 
)
Antihero for Hire (by the maker of Adventurers!)
8 Bit Theatre (a messed-up re-telling of Final Fantasy I)
Striptease (currently on hiatus. Cool filler art though. Admittedly, the hot women drew me in, but I also love the story, which can take odd, soap-opera-ey twists, and the characters.)
Something Positive (rather big spoiler in the final frame of today’s story . Cruel and biting, but with a big heart.)
A couple of more obscure ones that I love are Lulu Eightball and Perry Bible Fellowship. Lulu’s your basic Gen-X comedy but is occasionally hysterical. PBF’s all over the place, ranging from cute to sick. I believe both are featured in the online version of Baltimore City Paper.
I always have to brag when I hear people talk about PBF. The artist did his undergrad at my alma mater. I met him once. More well-adjusted than you’d imagine.
Another reader of Questionable Content. The page is always open in Opera.
I haven’t been a regular reader in a while, most because I just forgot about it, but a softer world is an interesting take on the webcomic. I’m not even sure if it counts as a webcomic. It has no plot, it’s just short little photomontages with little poems mixed in. It ranges from darkly funny, to just plain weird, to heartbreakingly sad, to all three at once. Not all of them are that great, but there have been a few that just blow my mind. Good stuff.
There was a thread a few days ago about Monopoly tokens. Check out the Tuesday (9/27) strip for Medium Large.
Take an hour or so and go through the archives.
Only User Friendly, Definately IT/computer oriented however.
I read Dilbert & Foxtrot on line but they are not truly Web Comics.
Webcomics:
[ul]
[li]Crap I Drew on my Lunchbreak[/li][li]Something Positive[/li][li]PVP Online[/li][li]Devil’s Panties[/li][li]The Illustrated Daily Scribble[/li][li]The Pet Professional[/li][li]Medium Large[/li][li]The Joy of Tech[/li][li]Pigborn[/li][/ul]
Print comics on the web: For better or for worse; 9 Chickweed Lane; Dykes to Watch Out For; This Modern World
Academy X when it updates.
Penny Arcade, because I spend time reading the forums at work (I don’t do that with this forum, or I’d never get anything done).
Achewood
8-bit Theater
VGCats, though it’s starting to ittitate me that most of the comics would be funnier if the last panel or three were removed.
Perry Bible Fellowship
Concerned: The Half Life and Death of Gordon Frohman
…a must for any Half Life Fan.
http://shortpacked.com/
[ul]
[li] Unshelved[/li][li] Cat and Girl[/li][li] Get Your War On[/li][li] White Ninja[/li][li] Alien Loves Predator[/li][li] Mac Hall[/li][li] Wigu[/li][li] Something Positive[/li]
[/ul]
I used to read Buttercup Festival which isn’t a webcomic as such, but a series of surreal, beautiful images. A bit like Exploding Dog, but more so. I also check PostSecret once a week. Anyone who hasn’t done so should check it out - it’s a collection of postcards this guy gets sent, each detailing somesone’s secret. Some are funny, some are heartbreaking. There’s no archive though, so I think I’m going to have to buy the book.
The great"Questionable Content" has already been mentioned,
I also read “Nothing Nice To Say”
and even try to get my own Webcomic going - the Zasivaci .
I’ve been trawling through the archve - there’s some great stuff in this! It reminds me of Buttercup Festival