The Simpson’s has so many and I stopped watching many years ago.
“Donuts. Is there anything they can’t do?” Like saving an out of control monorail.
“Oh, I didn’t get rich by writing a lot of checks.”
“Thanks Mayor Simpson. Because of you we’re all taking golden showers.”
Sorry for the list OP but I really do think these are some great lines.
It’s hard for me to think in terms of “single greatest” as there are so many that are just simply great, like Seinfeld’s “But I don’t wanna be a pirate!”.
Here’s an oldie from the episode “Return from Europe” in the old I Love Lucy series that offers two goodies in a row.
Lucy and Ricky are flying home from Europe and, desperate to bring home a large heavy cheese without incurring extra baggage fees, Lucy wraps it in a blanket, puts a bonnet on it, and pretends it’s a baby. As soon as he finds out what she’s up to, Ricky refuses to sit with her and moves to another seat.
A woman with an actual baby sits beside Lucy and tries to chat her up about their respective babies. When Ricky briefly returns and the woman realizes that this is the husband, she offers to switch seats so that Ricky can sit with his wife, which Lucy encourages.
RIcky, pointing angrily at Lucy’s “baby”:
“Not while you have that thing!”
Another one from Seinfeld: Jerry sings the theme song from The Bugs Bunny Show while he and Elaine are outside a theatre waiting for Pagliacci to start.
Elaine: You know, it is so sad. All your knowledge of high culture comes from Bugs Bunny cartoons.
If you can’t take a little bloody nose, maybe you ought to go back home, and crawl under your bed. It’s not safe out here! It’s wondrous… with treasures to satiate desires both subtle and gross; but it’s not for the timid
I saw that episode in the late nineties and never again, I still remember that quote more than 30 years later.
ETA: It was in the early nineties!, so almost 40 years.
“When you play the game of thrones, you win … or you die.”
Maybe the best of many many candidates from that show, will also throw in “You know nothing Jon Snow” and “That’s what I do; I drink, and I know things” as honorable mentions.
I was also tempted by this or one of many other Simpsons lines. It’s just by the time the Simpsons ended up on regular non-satalite TV in the UK Blackadder and The Young Ones has been ingrained in my consciousness for a decade or more, so it will never make my personal “best ever”