Hey there JF, welcome to riding.
This seems to be in the right forum, because all that follows is my own humble opinion. First off, I’d decide whether or not brand name makes a difference. No, we’ll get to whether the brand itself makes a difference, I am strictly talking about name here. If the type of people you are most likely to be riding with are all on Harleys, you might want to think twice about picking up a Honda. Do a bit of introspection and decide if Beemers are your thing, if you like the crotch rockets, or vintage Indians. Don’t discount this decision. While certainly possible that style does not make a difference, you need to be consciously aware of your feelings before you commit. I say decide this first because if you really won’t be happy unless you are on a Harley, why look at Kawasakis?
Next decide how you want to travel. Fast, slow, on and off road or only on, with lots of luggage or with just a bedroll? This starts to limit your choices a bit. Lots of things to carry and long distance riding? Consider a Full Dresser or a Goldwing. You mentioned lots of city riding but don’t discount weekend trips. This essentially helps you decide between a cruiser and a rocket.
Next comes size. How tall, etc. are you? It might not make a difference in this case, but if you are 5’1" , 190 pounds you might not want to start off with a thousand pounds of steel. If you are 6’ 7" 300 lbs., I don’t think you want a Honda 450. If you are in between, consider something in the range of 7-1200 CCs. These are large enough to maintain highway speeds, but also small enough to handle pretty well. I ride in city traffic (Washington, DC) and am grateful for the maneuverability of my bike. A smaller bike will also make it easier to learn.
From what I’ve heard Bike recommendations generally follow car recommendations - Jap bikes are generally put together better, but replacement parts and repairs are more expensive. American bikes have an air about them that you can only get with a Harley (though I heard Indians are coming back). They are a bit more expensive initially, a bit less reliable, but parts are cheaper and it is easier to find someone to work on it. Other foreign bikes have their followings (BMW, etc.) but are expensive as hell to repair.
Me? I cut my teeth on a 400CC Honda. Don’t ask me why, but it was stolen about four months after I got it. A year or so later I picked up a used Yamaha Maxim (XJ 700) and have been virtually trouble free for the past ten or so years. Shaft drive means a bit less power but much smoother rides. Great for making longer trips. Not the fastest out there, but I don’t ride fast so it does not bother me. It can cruise along between 70 and 80 if that is how the highway traffic is going.
Last word before my boss notices I’m on a message board: don’t take your wife for anything but a 'round the block ride for the first year. After the first month you may feel realll comfortable on your bike, you may think you can handle a rider. But someone on the back is going to dramatically change your handling. This might not seem like a big deal, but when that teenage punk or cellphoneasaurus unexpectedly cuts into your lane, you will want the experience under your belt BEFORE she gets on. And when you are ready to handle emergency situations with you wife on the back, have her take the same course you did. A passenger has just about as much (directional) control as the driver. Sorry to end on a preachy note here, but you’ll want her riding with you for a long time.
Keep us posted as to what you get… I hope I helped just a bit. Let me know if you have any specific q’s.
Rhythmdvl