Oh yes, the Comic Book Guy. I don’t know any comic book guys, actually, but there was this guy in our school who was pretty much exactly like him, just moreso. I’ve always predicted that one day, he’ll be a comic store owner - if he’s managed to stop living off his parents, that is.
My sister, and one of my high shool friends, both remind me of Bugs Bunny, although I can’t explain why. There’s something about their facial features - maybe the poofy cheeks? - that just calls Bugs to mind. I should also say that they’re both attractive women, and the fact that they remind ME of Bugs Bunny is a statement more about me than them.
And my youngest brother looks like Scooby Doo. Big soulful eyes, long face, big chin, smirking lips, no hair.
I’ve been told by a few people I remind them of a redheaded Tinkerbelle. Short, curvy and cranky. 
I was watching “Underdog” some many years ago. I realized that *Cad reminded me of **Zack Wilburn, an old classmate.
I was watching some of “Underdog” recently, and it had been so long I had totally forgotten about Cad. When he appeared, I thought the very same thought, “He looks like Zack Wilburn!”
Also, ***Mooch looks like a combination of Mike Mazurki and Broderick Cawford.
*Simon Bar Sinister’s #1 henchman.
**Not his real name.
***Riff-Raff’s #1 henchman.
Before my hair and beard went gray, I was a dead ringing for Brutus (or Bluto) from the Popeye cartoons.
Now I’m just old, fat, and scraggly
Is it just me? or does Prez Bush looks a lot like “Curious George”
and Cheney bears an uncanny resemblance to the “Man in the Hat”?
Not a cartoon character, but my elementary school music teacher looked a lot like Matt Foley, the motivational speaker character on SNL played by the late Chris Farley. He was big and fat and wore a similar style of glasses and the hair was similar. He even spoke loud and boisterously. Perhaps he really lived in a van down by the river, for all I know.
I had a teacher in my sophomore year who could have passed for Bluto/Brutus. He was just as much of a prick, too.
I have a friend who bears a disturbing resemblence to the baby vulture from the Bugs Bunny cartoons.
(Singing) “I am evil Ho-mer! I am evil Ho-mer!” 
By the way, Matt Groening has said that the Comic Book Guy is something of a self-parody.
I don’t know if I’m like any particular character, but there’s an anime series called Tenchi Muyo!… it got popular among my friends because each of the major characters bore a little bit of a resemblance to a friend… sometimes it was scary.
I work with a guy who looks like Muttley from The Wacky Racers. Same protruding brow, same sunken facial features, even the same stoop-shouldered posture. He doesn’t have the laugh, though.
From the episode in which Fat Tony’s gang rumbles with the Yakuzas:
“But, Marge, that little guy hasn’t done anything yet. Look at him. He’s going to do something and you know it’s going to be good.”
- Homer Simpson
My husband is that little guy.
My old boss was doctor Hibbert.
He wasn’t black or overweight but we all know that what makes Dr. Hibbert is the laugh and my boss had that to a T. Even the part about doing it at the most inopportune moments.
“A-hoo hoo hoo!”
Two fraternity brothers of mine were dead ringers for the following characters:
One was Fred Flintsone incarnate - a shock of black hair, square torso, square ankles, square square square. He reminded me of a living refridgerator.
Another was “The Chicken Hawk” from Foghorn Leghorn. John was a bodybuilder, and as a result he had a HUGE chest and wasp-waist, and he sort of leaned forward when he walked. I will never forget sitting in the living room (after having smoked an ungodly amount) and seeing him walk across the room in his posing trunks. It just hit me like a ton of bricks and I blurted out “Damn, John’s the Chicken Hawk!” Everyone present knew exactly what I meant.
My brother Andy reminds me of Spike from Cowboy Bebop.
Uncle Jim, my mother’s eldest brother = Tennessee Tuxedo.
It’s mostly the voice, but he also has very similar mannerisms and pompous attitude. He has not to my knowledge, however, ever worn a tux nor befriended a walrus.
The branch manager at the bank I used to work at looked like Dilbert, almost to a T.
My friend Jay could pass for Dilbert. He needs to change his glasses though. It’s mostly the body shape, but ever since he cut his hair, and you can see his face, the resemblance is uncanny.
I think my neighbor was the inspiration behind Beavis! Right down to that irritating voice.
Once worked at the Mercy Hospital pharmacy with a pharmacist who was a dead ringer for Barney Rubble.
A good gal-pal since college days: a slender but buxom babe with (until about 2 years ago) long dark hair who enjoys a drink now and then and has a pronounced surgical scarring all the way across her right lower ribcage, thus replicating Misato Katsuragi from the Evangelion anime.
Come to think of it, the husband of a friend of my mom’s reminds everybody of Fred Flintstone. Doesn’t look like him, but there’s just something that brings Freddy to mind.
I really don’t understand why tihs isn’t common knowledge across the US, but San Francisco Giants pitcher Kirk Rueter is the spitting image of Woody from Toy Story. His nickname is even Woody. Watching him pitch is damn spooky.