My first impulse was Jonathan Harris, because often people (even strangers on the subway) have told me that I look like Dr. Smith from Lost in space.
Actually, I’d like to be played by Orsen Wells.
Every time this question comes up, I say Ewan MacGregor (as in Trainspotting, not Star Wars).
I love his style, and I am sure he could do a nice, bland American accent. Physically, I don’t know if it’s a good choice or not.
You decide:
Angela Langsbury for physical type I guess.
I would have to say Rhett Butler, off of Grace Under Fire. Many of my friends tell me I’m a cross between her and Jean Smart of Designing Women
Thanks, you are the first/only person to suggest that Andy Warhol looks like me. 
How about Howdy Doody to play me? 
I’d really like Bill Murray. He’s got such a goofy charismatic presence he can save any stinker of a film (even one about me).
But for a close match, both in looks and personality, everyone says I remind them of Cameron from Ferris Bueller’s Day Off. He’s on Spin City now.
Jon Favreau. Not the “Gutter from P.C.U.” Jon Favreau, but the neurotic, head-too-big-for-his-body, dorky, awkward “Mike from Swingers” Jon Favreau.
I’d like to change my pick to Jason Lee, sort of a toned-down version of his character in MallRats. That pretty much covers me personality wise.
Hmmm. I’ve been told it would have to be a cross between Meg Ryan and Goldie Hawn.
Oh course I would like to say a young spitfire named Katherine Hepburn, but the budget for my bio movie would leave enough money for Ruth Buzzi.
I hope it’s Janeane Garofalo. But, it’ll probably be some no-namer soap actress, which I guess is just as well because the movie of my life would be pretty useless anyway.
Vince Vaughn.
Kim Novak, circa “Bell, Book and Candle.” (Well, a girl can dream, can’t she?) Okay, okay - it’s more like Eddie Izzard in drag - but he wears way more make-up than I do.
Eve: I’m up for the cameos - I DIG Eve Arden. The first smart-ass broad with brains and class!
[brachy scolding as Margaret Dumont]
Kiffa: Angela Landsbury??!?! Now don’t get me wrong, but surely you don’t mean in her “Murder She Wrote” days. Okay, I’ll accept Angela, but only from her “Picture of Dorian Grey” time.
[/brachy scolding as Margaret Dumont]
Jeffery Jones, better known as the principal in Ferris Bueller’s Day Off. Or the Evil Overlord in Howard the Duck.
Boy, I loved hearing that guy in Tech School call me evil overlord over and over again. <bitter sarcasm>
But not the lawyer from Devil’s Advocate. I don’t think that I’ll ever let myself get that big, and if I do, I’ll pay someone to beat 100lbs off my ass.
Fred Durst. I look just like him, down to the goatee and ball cap, though my cap is black, not red.
If I get to pick my own portrayer, I’d like it to be Julianne Moore. She can play the gammut from bitch (The Hand That Rocks The Cradle) to aloof seductress (An Ideal Husband) to passionate lover (The End of the Affair) with some comedienne (Nine Months) thrown in for good measure. And she’s a fiery redhead to boot!
Nick Cage in “Bringing out the Dead”. Something about the character in that movie I just really identified with.
Alfred E. Neuman 
I’m sorry for you.
I just watched that pile of poop last night.