OK, so far we have two solid lines that none of you are allowed to use because then it will sound a lot less clever when I do: newspaper horoscope and polar bears.
How funny!!! I was just thinking of starting a “What’s the best pickup line” type thread.
Okay here’s my favorite pickup line.
Setup…
I had gone out dancing at a club (many years ago when I was young and hot), and had just pulled my giant 1968 Buick Riviera into the crowded narrow dirt parking lot.
I was edging slowly toward the back of the building (where there was more parking) and this equally large and classic car was coming toward me, also carefully moving along the narrow parking lot aisle.
We were literally inching along because it was icy and snowy and we had such big cars. As our driver’s side windows came along side each other, the other driver (a cute guy) rolled down his window and motioned me to do the same.
I did and he said (key point, he said this very lighthearted, with ZERO sleaze or lechery),
“This is too tight of a fit for me NOT to know your name”.
It was just so spontaneous and funny!! I told him my name and agreed to save him a dance once I was inside.
Sadly, it was too crowded, and I never did find him, or he me (it’s possible he gave up on the parking situation and never came inside, this place got THAT crowded on weekends).
I definitely would have given him a dance, and possibly a date.
Again, the key was that he was just being silly and it was obvious he wasn’t being some sleazy player.
OH, and the other pickup line that worked for me (though not in the way I intended) is as follows:
I got this out of a cosmo (yeah go figure huh?), again when I was in my mid 20s.
The idea was that you would walk up to a cute guy, and to break the ice you would ask him:
“How many kisses do you think it would take you to get from my wrist to my neck”?
I thought, “well, that’s cute and fairly harmless” so I tried it out the next time I went out dancing. I found a nice guy and tried out the line.
He sat there and looked at my wrist, and then my neck. Then, he took hold of my wrist, placed it against my neck kissed my NECK and in the sexiest voice said “One”.
And yes, we went out!! We turned out to just be friends, but. …hey! It was fun. (gee I wish I were young again sometimes!!!).
Yeah, or she’ll think you’re calling her a polar bear, since the majority of females are paranoid about their weight! 
I think confidence without arrogance is the key. Most of my successes have been while I was slightly under the influence, or if I was in a good, confident mood for whatever reason. Then you can just make a passing comment on anything non-offensive, and if she likes the look of you, a conversation will commence.
I have a friend who will make all the guys in here sick though… being a loud, confident guy, he walked past two young girls making out together in a bar and said idly, “You want to try that with a man!”
They did. The lucky b*****d!
HAHA! That’s good! Too bad I don’t come across very many girls making out though. 
OK, none of mine work coz I’m way too shy but I’ll quote one of my friends, whose line makes it seem all too easy:
Friend: Hi
Girl: Hi
Friend: Ok, just hang on, I need to come up with a pickup line here… (thinking)…
Girl: (Laughs) Aww, you don’t need to!
‘Friend’ had a big smile the next day :dubious: