H.P. Lovecraft meets Left Behind!
Yahweh is toast! 
I’d still like to see Cthulhu meet the Aztec deities.
Let the Old Ones meet some real hard cases.
Sushi order, right up!
Chalchicultlu, Goddess Of The Jade Petticoat
You get her attention by dropping jade objects into bottomless sacred wells.
She saved mankind by turning them into fishes.
Xipe Totec, The Flayed One
Worshippers skinned a living maiden and dressed a boy in the skin
Quetzacoatl, The Feathered Serpent
Manifested as a giant snake, with feathers, the face of a jaguar, and human eyes
“New god wants human sacrifice, and for us to have sex with fishpeople”
Introduce Cthulhu to the Aztec gods and nobody would notice.
What about The Untouchables meets Star Wars?
Obi-Wan Connery: “You wanna get Darth Capone? Here’s how you get him: He pulls a Saber, you pull a blaster. He sends one of yours to the Dentention Block, you send one of his to the morgue. That’s the Jedi way!”
Or
“Isn’t that just like a Sith? Brings a Saber to a blaster fight.”
Utterly, dastardly, horribly wrong:
Popeye the Sailor Moon:
Nothing dirty on the link, but… no I didn’t like to see that, and neither do you…
http://www.stacken.kth.se/~foo/weekpics/popeye.png
http://www.stacken.kth.se/~foo/weekpics/weekpics.shtml
Well, I did warn you… 
Almost Hello Cthulhu
The Gilligan’s Island. After being lost in a storm during a “three-hour tour”, a boatload of tourists washes ashore on an island inhabited by the descendents of pirates, who enslave, torture and rape the castaways. Every week a new plan is formed to escape and every week it’s ruined by the imbecility of the ship’s first mate.
I’d pay good money to see a cross-over between Gilligan’s Island and The Most Dangerous Game.
The Lost Boys and **West Side Story. ** I want musical dancing vampires!
CHUD meets Friends…Not so easy in the big city now, is it?
Jack Bauer washes up on the Lost island…
In 24 hours he will have killed every Other, opened every hatch and used that stupid computer to send a signal for Chloe to dispatch the CTU helicopter to pick him up.
What, that episode of Get Smart wasn’t enough for you?