I have never been rude or hostile to a guy because he made a single (socially appropriate) expression of interest (the gropey or vulgar guys yes, but they deserved it), nor have I personally witnessed such behavior from my female friends. I have, however, been rude and hostile to men (and seen others do so) AFTER they have ignored “polite rejection”, “polite but firm rejection”, and “barely civil point-blank rejection”.
If you are determined to make a nuisance of yourself, you are going to be treated like a nuisance. What do you find so offensive about that idea? Why should women be obliged to be endlessly nice to men who are being obnoxiously pushy? Once I’ve said NO, repeatedly, and you’ve ignored me, repeatedly, I no longer have to be polite to you.