Jaguars at Ravens: The Ravens should win this one. Then again, the Ravens should have stomped the Brown flat, not lost by 10 points. So it depends on the Jaguars. Make of this what you will. 
Vikings at Buccaneers: Ah, the crumbling sorta-dynasty against the perennial also-rans. Prediction - Someone makes a totally moronic blunder which a junior high schooler could avoid which costs his team the game, infuriating a whole bunch of gamblers.
Bengals at Lions: If the Bengals don’t win this one, I’ll…uh…spend more time on yardwork than usual this week. Yeah. (I know the Lions are abysmal, but I don’t trust the Bengals at this point.)
49ers at Bears: Conventional wisdom says that the Bears can’t win five in a row. Of course, if you bet according to conventional wisdom this season, you’d better have a sturdy refrigerator carton handy, if you catch my drift. Bears should win and cover the spread, although not by much.
Saints at Rams: Does anyone else see the irony about a 6-0 team “running up the score” (like anyone’s going to give a crap in the NFL)? See, if they were 2-4, and they were running it up against weak opponents, that’d be disgusting. But they’re pulling out the stops against everybody, leading me to believe that that’s just how their offense works. Anyway, I don’t think the Saints have the weapons to stop them.
Jets at Panthers: Good call, Omniscient. Might want to rethink the Vikings-Buccaneers game as well. The Jets, of course, have a lot more to play for (playoffs + that New York thing), which means that they’ll either 1) play inspiring football and win big or 2) choke and lose big. And they’re 3-3, so who the hell knows??
Cardinals at Cowboys: Oh god. On paper, the Cardinals should win handily, as the Cowboys are at rock bottom righ tnow. But that should be little comfort to a unit that’s something like 4-500,000,000 against Dallas. Sheesh, if Buddy Ryan coudln’t win this one…Prediction - The Cardinals go up by 56 with four minutes remaining, then give up 49 unanswered points. Then with one second remaining, the Cowboys return a punt 93 yards for a touchdown. But Arizona blocks the extra point and wins 56-55. (Don’t laugh…last year’s Cardinals-Redskins game was even weirder than this.)
Raiders at Eagles: The Raiders have been winning, but not impressively. The Eagles are atop the division, but they’re prone to a letdown at any time. This is going to be tight.
Patriots at Broncos: Another game where both teams have disappointed. Prediction - If the Ewing Theory still has steam, Patriots win easily. Otherwise it’s a toss-up.
Bills at Chargers: The Bills have something of a quarterback controversy. Yeah, like the Lions have had for ages. Prediction - The Chargers take another step toward a repeat of their last Super Bowl run.
Dolphins at Seahawks: Assuming that the Patriots return to form, the Dolphins have an opportunity to pull away in the AFC East. Thanks to convincing wins over Jacksonville and Denver, the Seahawks are still under High Expectations, meaning that the Dolphins should run away with this one.
Giants at Redskins: Man, the Giants *better win…
Titans at Steelers: The Titans are “recovering”. The Steelers are overrated, Kordellized, whatever…
Big footballin’ deal. Steelers in a blowout.
(Yes, this was a “spite” pick. Your point? :D)