Super-powerful villains who can be defeated (or greatly hindered) by the lowest of heroes

Juggernaut…Shadow Lass. (I know she’s not Marvel) Dudes gotta see right? Yeah he can rampage away but with a bubble of darkness on his head, he’s greatly hindered. He can’t fly either. Speaking of which:

Doomsday…Gnort. Gnort has a power ring. Power rings can teleport. Bye Doomsday. Have fun in the middle of a red sun. Or if the ring cant reach that far, teleport him in a series of ports.

Superboy Prime…Matter-Eater Lad. Chomp.

Hulk…Kitty Pryde. Hulk phase. Hulk sink. Kitty let go. Hulk dead. Or Gateway. Say hello to the center of the Earth Hulk. Hope you survive. You cant see. and even if he can survive there, how long will it take to swim to the crust and start digging? I dunno, but wake Gateway up when he gets out so Hulk can start all over.

Lobo vs. Phantom Girl (of the Legion). That one happened. She taunted him, he attacked, couldn’t hit her, tried again. And again. Eventually he passed out from the effort.

The third X-Men movie was mostly bad, but it did have one good scene in which Kitty Pryde used her brain to defeat Juggernaut’s brawn.

There was an issue of X-Men where Kitty did partially phase the Hulk into the ground. He pulled himself out and was fine.

Anyone vs. Squirrel Girl, of course.

Well then do the Miracleman approach and phase a girder into him.

Sauron vs Hobbit
Goliath vs David
Luke Vs Empire

Fiction is replete with the concept of the Underdog moving to Victory.

Oddly poetically, a few of Batman’s most threatening archnemeses could be defeated by a random lowlife with a cheap gun in the right place at the wrong time. Just like in real life.

Well, you know, it wasn’t Matter Eater Lad but the similarly lame (and also in the Legion of Super Heroes) Bouncing Boy who squared off against the omnipowerful Duplicate Boy over Duo Damsel.
And in Phil Foglio’s run in Angel and the Ape, Sam Simeon easily defeats Gorilla Grodd with a Junk Food stratagem.

Darkseid vs. The Atom. The Atom shrunk down to photon-size, rode a beam of light onto O’Deadly’s head, grew a bit, climbed in an ear and proceeded along the the brain, where he caused great mayhem.

Grandmaster vs. Hawkeye. Grandmaster sent the dead superheroes and villains in a game against the heroes (mainly the Avengers). After round one was over, he sent the dead again, this time with the additions of those heroes who fell in round one. Rinse and repeat, and we find ourselves at Everybody in the Universe vs. Captain America and Hawkeye. Cap’s ready to die fighting. Hawkeye, that old carny, appeals to Grandmaster’s gambling nature to risk it all on a simple game of chance. He breaks an arrow in two, and says “pick the longer piece”. Grandmaster picks the short piece and the universe is saved. Cap is then shocked (shocked, I tell you) to find out Hawkeye “forced” the Grandmaster to pick the short one in order to save the universe.

Nemesis Kid vs. Duo Damsel. He can defeat any ONE person, she can split into TWO people. HA! HA!

If i recall, he also defeated his brother The Collector in the Korvac Saga. Just bounced an arrow off a wall in an all or nothing shot.

I’m almost positive this has happened.

Goliath… David.

Some of you may be too young to remember that comic when it was current.

There was an LSH adventure in which the combined might of almost the entire LSH were up against an opponent (Omen?) who trashed everyone, even Mon-el, Ultra Boy, Blok, and all the heavy hitters. In the end, Shadow Lass somehow figured out that their opponent was gaining strength by absorbing solar radiation through his eyes. She cast a shadow over his eyes, and BAM! Down for the count.

Likewise, there is the landmark “Omega” story in which a mentally unbalanced Brainiac-5 turns traitor and uses the Miracle Machine to create Omega, a monster capable of punching out both Mon-el and Superboy. After handily plowing through the entire LSH, he’s defeated by Matter Eater Lad, who eats the Miracle Machine, causing Omega to implode.

Yep.

Is that how Triplicate Girl became Duo Damsel?

Wasn’t David the favorite, though? He was highly skilled with a ranged weapon (even without Yahweh intervening). It was like taking a gun to a knife-fight.

Eclipso, a pretty nasty villain, could be defeated by any character who could produce a blinding flash of light. Sun Boy comes to mind. And, by the way, Ike Witt, Triplicate Girl’s “third body” was killed by Computo.

IIRC, this was the fate of Brother Eye, Batman’s secret emergency countermeasure against the world’s supers: in a But Something Went Wrong scenario, it started doing its reconfigure-androids-with-the-specific-abilities-to-defeat-this-or-that-hero thing such that folks were in grave danger and people with great powers and exploitable weaknesses were targets and Who Knows What would ensue.

You want to send in someone with a kryptonite allergy? Yeah, that’s not going to work. You want to send in X, or Y, or Z? No. Can. Do: Brother Eye will see them coming, and react with a defense specifically tailored to the would-be attacker.

Mister Terrific isn’t bulletproof; he doesn’t have freeze breath, he can’t change into a mighty giant; really, he only has one trick up his sleeve. But the key is, it didn’t see him coming, because he’s invisible to electronics. Hey, is that an ‘off’ switch?