My personal favorite, which usually comes up at least once each presidential election cycle:
What would happen if all members of the Executive Branch, Congress, and the Supreme Court were killed at the same time in a terrorist attack?
Sorry if it’s been mentioned and I missed it, but what’s that one? 14k in a something something?
In a -gry. 
I hate bad drivers!
Get damn cyclists off the damn sidewalks!!1!
Invariably started five minutes before Shabbos or a major Jewish holiday.
Out-of-state speeding ticket, nothing bad will happen if I just ignore it, right?
Tell me your vasectomy experience
Learn how to do a zipper merge, moron
I’m going blind/can’t breathe/am bleeding from my ears, should I make a doctor’s appointment?
Why do people watch soccer? It’s so boring and no one ever scores.
Litter box problem
My neighbors are noisy/dirty/mean and I hate them
Going on vacation to Turdbucket, ND, where should I eat?
Should I tip my Nice Guy declawed cat/pitbull hybrid for raping the goat behind one of Monty’s doors on an airplane on a treadmill?
Dude, just read that thread and walk away slowly.
There are some things man was just not meant to discuss.
What should I do with leftover ______?
I don’t know. Eat it?
That’s just crazy talk.