Have to go with Sheldon. He was the cartoonist when I was in undergrad. I missed little Sheldon, and was overjoyed when I found out he was online.
Well, almost all of my favorites have been mentioned. Ozy and Millie is my very favorite; I really think its distribution should be expanded to print media. Pure genius.
I also really like Sinfest, Schlock Mercenary, Goats, Boxjam’s Doodle, and Pentasmal.
However, there is one I really like that hasn’t been mentioned yet, and martinez, if you go for British comic strips, check out Bobbins. It’s awesome.
I don’t get it.
Modern comics seem to be extremely not funny - they appear to believe that you take an absurd premise and say inane things, draw them in a cookie-cutter style that often displays no talent, and that’s enough to expect a laugh.
Well, it seems to work for them, they sure do get a following. Except that I see nothing humorous in them whatsoever.
I really don’t get it.
lurker, you are my new hero. THANK YOU SO MUCH.
I especially enjoy Slow Wave, a weekly strip featuring real dreams dreamed by real people.
While that’s certainly the case with printed comics, and a fair number of webcomics, there are some very good online ones. Try Keenspot for a listing of some of the best ones, or just follow some of the reccomendations in this thread.
Well, a lot of online comics are in serial form, so if you try to read a random strip without starting from the beginning of a story arc you probably won’t get it. Sluggy Freelance is a great example of this.
My top three absolute favourites have got to be:
Exploitation Now : My first webcomic, and most of the time my favourite. Poe has an odd sense of humor and if you don’t mind the occasional nudity it is a rather good one.
MegaTokyo : Piro may get a lot of crap from some people because of his sometimes irregular updating schedule, but in all honesty this comic is so worth whatever wait there may be.
Penny Arcade : Tycho and Gabe are some sick guys, but lord are they funny.
I’ve been reading these three religiously for way over a year now and I recommend them to anybody 
Hands down, RPG World (www.rpgworldcomic.com)
It’s been ages since I’ve played a console RPG, and I’m riveted to each new episode. Ian J. is a true rarity; he’s created a complex story that’s a dead-on pardoy of its source material which is also funny, and it’s always moving forward, never stagnating. It’s a joy to read.
So is his “regular” comic, Iancomix (ianj.keenspace.com), although he does that one a lot more sporadically.
Ruffhouse (www.rowdyruff.net/ruffhouse.shtml) is a satirical take on the members of the hosting Powerpuff Girls website. It’s pretty dang funny most of the time.
While not strictly webcomics, I also heartily recommend This Modern World (www.thismodernworld.com) and Dykes To Watch Out For (in the comics section of www.planetout.com/pno). Tremendous wisdom and a refreshing change of pace from the conservative mindset which is abolutely saturating the media these days.
Sinfest…I kinda like it, but it comes across as a poor man’s Bloom County.
As for Sexy Losers…ugh. I’ve seen about six episodes, and I’m already sick to my stomach. I’ve never, ever seen “humor” about people who “don’t get any” that was even marginally funny or even readable. I actively loathe this brand of humor. Good lord, why does anyone find this funny??