I vote for Faye Valentine of Cowboy Bebop.
She’s smart.
Very Dangerous!
And she has a REALLY cool ride! Beats all h**l out of a 76 Gremlin, don’t it? 
Totally cool!
BTW–for the impaired, I point out that there are links. 'Kay?
I’m showing my age, but so what.
- Bugs Bunny (Old school WB cartoons, not the new ones)
- Bullwinkle Moose
- Kim Possible
- The Brain (Of “Pinky & The Brain”)
- Mojo Jojo.
The Iron Giant
Nichals D. Wolfwood of Trigun. Spike Spiegel is a very close second. I also always admired Dr. Quest and his ‘special friend’, Race Bannon…
Bug Bunny
Samurai Jack
Raphael (Ninja Turtle)
Batman
Bender “Bending” Rodriguez
Dr. Zoidberg (Hooray, i’m useful again!)
Morbo
Damnit. I wanted to be the first to mention Bender, the robot. (Robot pronounced in true Dr. Zoidberg format.)
Eugene the Jeep
The ONLY 4-Demensional Character
Jubei Kibagami or Himura Kenshin.
What? This far along and not one Homer Simpson, or even one Simpsons character?
Pea-tear Griffin… Ah crap.
Tie between Benton Quest and Johnny Bravo.
The Brave Little Toaster.
Or Bart Simpson.
OH, ** Evil Captor** I forgot about Johnny Bravo!!!
He’s da coolest! Hooah, pretty mama.
Porco Rosso. Anti-fascist ace aviator who just happens to be a pig.
Marco, of Porco Rosso fame. A noble anti-fascist freedom fighter and bounty hunter of pig persuasion.
Faye Valentine.
Spike Spiegel and Wolfwood.
CyberPundit, we’re like, on the same cosmic plane. Dude.
Without a doubt, Daria Morgendorffer. Jane Lane is a close second.
Chilly Willy.
Runs, ducking projectiles.
Voltron
Aeon Flux
Daria
Zorak
Speed Racer