So I was right, then!
I Dream of Jeannie (1965–1970) was set in Florida.
“Take a peak”???
Damn it…. Came here to post that but wanted to read thread first.
Typo. Happens.
Nope, Arkansas. Therefore Designing Women ('86-'93), set in Atlanta, might fit for Georgia.
The Chicago Teddy Bears (1971) predated Bob Newhart’s show for Illinois by a year.
If we’re doing DC, The Farmer’s Daughter (1963–66) predates Get Smart.
Mary Kay and Johnny was the first American sitcom, but Pinwright’s Progress predates it.
That’s the later one then because Alice was set in Phoenix and aired 1976 - 1985
Ninja’d by suryani because I searched for ‘Arizona.’
The Phil Silvers Show was set in Fort Baxter, Kansas and premiered in 1955.
The execrable At Ease starring Jimmie ‘JJ’ Walker was set in Texas and aired in 1983. It was loosely based on Phil Silvers’ Sgt. Bilko character.
ETA: Somehow I missed terentii’s post above for The Rounders from 1966 in Texas.
Is Our Miss Brooks set in Madison, WI? I know she teaches at “Madison High School”, but I’m not sure the state is ever mentioned (having never seen an episode) (my searches for “Our Miss Brooks state” don’t help.
Brian
I believe there is, but the problems for our task are that (1) the state categories aren’t subcategorized according to the type of show (sitcom, etc.), (2) many shows are missing from the categories, and (3) some shows are miscategorized, or at least are put into a category without any firm evidence that they really belong there. Regarding the first problem, clicking through to a show will often reveal whether it’s a sitcom (since sitcoms are put into a parallel category and/or are described as such in the text of the article) but who has time to click on thousands of shows to check?
A “Madison High School” doesn’t mean much at all, because it’s quite common for schools to be named after presidents. Which makes Presidential-named schools convenient for fiction, because they could be any school, anywhere.
If animated shows count, then South Park (Colorado) is also still running.
Animated shows count as long as they’re situation comedies.
Would Cougar Town (2009-2015) work for Florida? The town doesn’t exist but it is set in Florida, and I believe it is a sitcom.
Well, it still fills in an empty slot. 
New Jersey. Charles in Charge. 1984-90.
New Brunswick
A short lived one—
We’ll Get By. 1975. Created by Alan Alda.
1959-1964:
Bullwinkle shared a house with his best friend Rocket J. Squirrel in the fictional small town of Frostbite Falls, Minnesota, a spoof of the real-life American town of International Falls, Minnesota.
But IDK…it was always “Rocky and Friends,” so it was a sketch among other sketches, may not qualify as a sitcom due to brevity.
Yes, but those sketches stretched over several shows, so that takes care of the “brevity” issue.