I didn’t see a thread about this–
I once strolled up to this gorgeous guy in a bar (and I had no make up on, a big oversized shirt–BUT I had had 6 beers) and said:
Don’t I know you from somewhere?
He came home with me and stayed for 3 months.
The first words my husband ever said to me were “Are you one of the people I’m supposed to be meeting to go to Callaway Gardens?” I wasn’t. I married him 11 years later and we’ve been married for 15 years now.
The one that makes me laugh is, “Nice shoes. Wanna f*ck?” Doesn’t work on me, but makes me giggle.
Somehow I was able to turn “Name?” into a six month relationship.
(Well I mean, heck, if I’m going to hit on her, may as well have somethin to call her beyond “toots.”)
My dude was Poncho, and I was Lefty. It was the wildest, most intensely passionate experience I had ever had.
It was before the era of AIDS-- before free love started carrying a heavy price.
Before I became (gasp) middle-aged. 
My brother likes to look helpless in the grocery store, and ask an attractive woman, “Excuse me, but where can I find the toast?”
You can always lick your fingertip, touch it to a garment being worn by your intended target, and then say, “Wow. We’ve should get you outta these wet clothes.” You might get slapped, but hey-no stones, no blue chips. 
The most interesting pick-up line anybody ever used on me was “That guy who figured out how to disprove spontaneous generation was pretty damned smart.” Didn’t work because it soon became clear he was a total ass (he actually thought that I’d be intimidated by his ‘intellect’ because he knew what spontaneous generation was and he thought for some odd reason I wouldn’t know what it was), but I still have to give it nerts for originality.
Once at work many years ago a very drunk [female] guest with a sexy voice asked “What time do you get off tonight?” Stupidly I replied “11:00”. She followed with “Can I watch?”
I’ve read the following on various gag sites that assert they’ve all been used:
“Were your parents terrorists? Because baby, you’re the bomb?”
“Were your parents assholes? Because baby, you’re the shit.”
“If I said you had a beautiful body would you hold it against me, and by hold it against me I mean f*ck?”
“What do you say we blow this place and each other?”
Hey Sampiro: What the hell is spontaneous generation? Never heard of that…
The line that’s always worked the best for me has been some variation of: “Let’s dance”. Pick a good song to use it with, though. And maybe, if you’re not much of a dancer, it’s not the line for you.
Pick-up lines are useless if you are not, or cannot convincingly pretend to be, a guy for whom pickup lines work. Most women can easily smell out incoherent body language, and any idiot can tell that you’ve been on the Internet memorizing line after line if the best you can do is wobble up to her, blurt out the line and then stand there like a retarded deer caught in her headlights. The trick is to convince her that she’s hitting on you. Make eye contact from a distance, make your way over and tell her that you don’t like being treated like a piece of meat, and that women nowadays have no respect for men. Give a small speech on women’s rights, replacing, of course, “women” with “men”, and if at any point she touches or brushes against you, make a big deal out of it and exclaim that all she wants is your body. Given you are drunk/brave/good enough, you will eventually erode her will and she will come home with you.
Can’t offer anything interesting on the female side, though - seems like all you womenfolk have to do is sit around with your friends and look pretty. It ain’t fair, I tell ya.
I had no idea what spontaneous generation was either so did a bit of reading , now I understand the concept and how it could be disproved but I can’t see how “That guy who figured out how to disprove spontaneous generation was pretty damned smart” translates into a pick-up line.
Because it’s funny. Like Seinfeld in the elevator: “You know those crop circles? Yeah, that’s me.”