Mine works, try it. The others could get you a black eye.
Can I buy you a drink…or do you just want the cash?
I remember discussing this subject with some girls at lunch back when I was in high school. We came to the conclusion that just about the only way a guy could make a cheesy pickup line work would be if he could deliver it in an ironic sort of way that would make it clear to the recipient that he’s really making fun of guys who use cheesy pickup lines. This would probably be difficult to pull off, but could be quite effective if done properly.
There was a male student teacher in the room with us, and he said that he never used pickup lines, he just said “Hey there!” and the women came to him. Right at that moment a female student teacher walked into the room. She was very confused when we all started laughing. 
Can I buy you a drink?..no…Okay can I buy you a Corvette?
At a bar once, we overheard this guy come up to a group of girls at the table next to us and say “My friend dared me to come over and talk to you.”
We started laughing amonst ourselves and, about five minutes later, one of the guys in our group went over to the girls’ table and said “My friends dared me to go kick that guy’s ass.”
Though there’s one sure fire pick up line that I have NEVER seen fail: “Hi, my name’s Cecil Adams.”
I have never had this one fail (from tall, reasonably attractive female to male-of-choice)
‘I find you attractive. I’d like to sleep with you, no strings attached.’ (Specify a specific date if tonight isn’t good) You may need to repeat it a few times, to get their brains to engage long enough to actually reply. ::wicked grin::
Granted, I did accidentally fall in love with the second guy I used this on, but he fell for me, too.
As for lines that work on women, the only thing that has worked on me is actual conversation and emotional courage. lines have only made me laugh - and not in a good way.
Here’s one that generally works.
Wanna go do a line?
or also
Wanna go smoke some weed?
of course this is in SF, where everyon does drugs. I don’t know how it would fly in some other more conservative areas.
Seriously does works though.
Wow, Oldscratch. What a great way to turn my smile at reading this thread to a sad frown. 
“Yeah, I’ve got the time. Do you have the energy?”
If you can believe it, an aquaintance told me that this line worked once:
“Yo, you’ll do.”
There’s a Muddy Waters song in which he says:
“Something about you, baby, brings out the beast in me.”
Except that it sounds like he’s saying:
“Su’um 'bout you, baby, brang out the beef in me.”
My friends and I often joked about this as a pick-up line. Obviously, any girl who immediately recognized the reference was liable to be pretty cool. She might also recognize some of my other favorite misheard blues lyrics:
“I got my brains on you.”
“You gonna need King Jesus on your bone.”
“When I woke up this mornin’, all my hair was gone.”
This one is untried, because frankly, I lack the guts. And in fact, I really think it is only to be tried on men, because if it was attempted on a woman, she might attack.
I’ll bet you one dollar [brandish dollar] I can kiss you without touching you. [kiss recipiant. Tuck dollar into pocket.] Oops. Guess I loose.
I like this one that I just read: “I lost my puppy, can you help me find him? I think he went into that cheap motel room over there.”
Okay, my favorite line so far is the first one, “got any?” which I think might be even more effective if followed by, “well, gimme some”.
One of the worst I have ever heard was used on my sister…
Dude: Do you want to be wild and free?
Sis: Not with you.
The best I have ever heard was from the world’s, possibly the galaxy’s most gorgeous bartender.
him: So, why do blondes have more fun?
me: Um, I don’t know. Why?
him: Because there aren’t enough redheads to go around.
sigh
Of course it only works on redheads. But it worked.
“Is it hot in here, or is it just you?”
“Hi, I couldn’t think of a pickup line so I thought I’d just come over and say hello”
-This actually works pretty good.
…or alternatively,
“Hi I couldn’t think of a good pickup line, do you know any?”
Oh my god! … that page is freaking hilarious … that is right boys and girls, so funny it freaks!
My favorite so far:
" You seem to have lost your nipples. Quick, grab mine. "