Are we talking about the same Tales of the Questor? 
Personally, I think 65 strips (as of last Sunday) is a good run for a once-a-week web comic, especially since he averages around 9 panels a strip, chock-full-o’-story.
Hm. Well, everyone already got most of the good ones, but if you don’t mind something just starting out (comparitivly), then The Dementia of Magic (http://www.dementia.keenspace.com) is a good, plot-based silly fantasy comic. I can’t say much for the art, but the story is nice and the characters good. (The fact that it’s made by a friend of mine that needs some publicty has nothing to do with this post.)
www.choppingblock.org is good for a one-frame, black humor strip.
Also, another vote for something positive. Love, love, love.
Check out the gaggle of talented and goofy comic auteurs at iComix. Many of them are alumni (read: survivors) of UT’s Daily Texan comic pages. Sorry, no Nutty, though.
You Damn Kid is usually good for a laugh, but it updates like a spastic colon.
Nobody has mentioned the SDMB’s own Chef Troy’s strip, Scandal Sheet, which is pretty good as well.
The DFC Archive is very funny. Rather crude, and not exactly a webcomic, more a re-captioning effort, but a web classic nevertheless.
Bless you. Ever since Spinnwebe finally yanked his unlinked-to archive from spinnoff.com, I thought the DFC had perished forever. Ah, those were happier times.
My personal favorite (and I am, obviously, heavily biased) is Marty Gray.
http://www.strangevoices.com/strangevoices/martygray.asp
Of course, you should start at the beginning. Today’s strip by itself makes zero sense:
http://www.strangevoices.com/strangevoices/toongifs/toon001.gif
(and then laboriously change the number of the URL-- “…002.gif”, “…003.gif”, etc., to “…toon100.gif”)
I’ve been checking pretty much everything that a. I don’t know already, b. isn’t based on antropomorphized animals, especially the kind with boobies, c. doesn’t have sprites and d. doesn’t look otherwise lame, and have found several gems.
Something Positive looks like a candidate on my must-read list (with Sinfest, PvP, Sexy Losers and Sluggy Freelance), and As If! and Scary Go Round look like strong candidates, too. I’m also liking what I’ve seen so far of Checkerboard Nightmare, Boy Meets Boy and Soap on a Rope. Return to Sender is great, but looks like pretty scarcely-updated.
But all in all, thanks for all the good web-comic recommendations! I’d use a thumbs-up smiley (“thumbey”?) if this board had one.
A lot of my favorites have come up already, but not my two absolute, die-hard favorites.
Achewood, while a little hard to get into, is just about the most quality comic out there, IMHO. Character driven, esoteric, downright weird at times, but spectacular.
Cat and Girl is about, surprisingly, a cat and a girl. The girl is indie and over-educated, the cat is, well, not. If you’re sick of hearing people talk about ‘meta’, this is the comic for you. Also check out her other projects, The Adventures of Death and The Four Fours (and a special one-time comic titled “The Secret World of Sarah Vowell”)
For those who liked, Derek Kirk Kim’s Small Stories, here’s another I enjoyed: When I Am King, by demian.
effac3d, I’ll second the suggestion of “Sexy Losers”, but I don’t know if “a bit objectionable” really covers it. On the other hand, I don’t know how to describe humour based largely on incest, chronic masturbation, bukkake, and necrophillia that’s both very funny and somehow almost inoffensive.