My favorite Simpsons exchange of all time puts all others in a tie for second:
Stacy Lavelle (creator of Malibu Stacy): I was forced out in 1974. They said my way of thinking just wasn’t cost effective.
Lisa: [gasps] That’s awful.
Stacy: Well, that, and I was funneling profits to the Viet Cong.
Marge (complaining of boredom): Last week, some Jeohvah’s witnesses came to the door, and I wouldn’t let them leave. They snuck away when I went into the kitchen to get more lemonade.
(Homer deals Blackjack to James Bond and Blofeld)
Blofeld: 20. Your move, Mr. Bond.
Bond: I’ll take a hit, dealer. [Homer gives him a card] Joker! You were supposed to take those out of the deck.
Homer: Oh, sorry. Here’s another one.
Bond: What’s this card? “Rules for Draw and Stud Poker”?
Blofeld: What a pity, Mr. Bond. [Odd Job and Jaws grab Bond and drag him out]
Bond: But…but it’s Homer’s fault! I didn’t lose. I never lose! Well, at least tell me the details of your plot for world domination.
Blofeld: Ho ho ho, I’m not going to fall for that one again.
Bart: Hey, dad, can I use the transporter sometimes? Please, I swear I’ll be careful!
Homer: Sorry, but this is a highly sophisti-ma-cated doo-wacky. If you don’t use it responsibly, KA-BLAM-O! (Homer outstretches his arms to add emphasis. One of them goes into the matter transporter.)
Lisa: (in another room of the house) Ow, somebody just punched me in the face!
Homer: It was your mother!
And later: Bart! Did someone forget our little KA-BLAM-O! talk?
I use highly sophisti-macted doo-whackey all the time. 'Course, I work in IT, so we have a fair number of said doo-whackeys around.
Homer: “Aw, Marge, you know every time I learn something new something old gets pushed out. Remember the time you bought me that home wine-making kit and I forgot how to drive?”
Cecil comes to pay bail for Bob and give him a job?
Bob: Are you sure you want to do this? You have heard about the murder trial?
Cecil: I’m afraid not. You see, I’ve been living in a small cave on the moon for the last six months.
Bob: [tired, flat] Touché, Cecil.
(After receiving something like 50 cents for selling grease)
Bart: But dad, that bacon cost 20 dollars!
Homer: Yes, but your mother paid for that.
Bart: But doesn’t she get her money from you?
Homer: and I get my money from grease, what’s the problem?
Homer(to Mr. Burns): Could you repeat the part of the stuff where you said all about the things? …the things?
Homer(answers the phone): Yello. You’ll have to speak up, I’m wearing a towel.
Homer: Oh, yeah? What are you gonna do? Release the dogs? Or the bees? Or the dogs with bees in their mouths, and when they bark, they shoot bees at you?